Molecular physiology of glucose transporters

Bernard Thorens, Maureen J. Charron, Harvey F. Lodish

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Molecular cloning of cDNA encoding the human erythrocyte facilitated-diffusion glucose transporter (GT) has elucidated its structure and has permitted a careful study of its tissue distribution and of its involvement in processes such as insulin-stimulated glucose uptake by adipose cells or transformation-induced increase in glucose metabolism. An important outcome of these studies was the discovery that additional isoforms of this transporter were expressed in a tissue-specific manner; these comprise a family of structurally and functionally related molecules. Their tissue distribution, differences in kinetic properties, and differential regulation by ambient glucose and insulin levels suggest that they play specific roles in the control of glucose homeostasis. Herein, we will discuss the structure of three members of the GT family: erythroid/brain GT, liver GT, and adipose cell/muscle GT. In the light of their tissue-specific expression, kinetic parameters, and susceptibility to insulin action, we discuss their possible specific functions.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalDiabetes Care
Volume13
Issue number3
StatePublished - Mar 1990
Externally publishedYes

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Facilitative Glucose Transport Proteins
Glucose
Tissue Distribution
Insulin
Facilitated Diffusion
Molecular Cloning
Muscle Cells
Protein Isoforms
Homeostasis
Complementary DNA
Erythrocytes
Outcome Assessment (Health Care)
Liver
Brain

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Thorens, B., Charron, M. J., & Lodish, H. F. (1990). Molecular physiology of glucose transporters. Diabetes Care, 13(3), 209-218.

Molecular physiology of glucose transporters. / Thorens, Bernard; Charron, Maureen J.; Lodish, Harvey F.

In: Diabetes Care, Vol. 13, No. 3, 03.1990, p. 209-218.

Research output: Contribution to journalArticle

Thorens, B, Charron, MJ & Lodish, HF 1990, 'Molecular physiology of glucose transporters', Diabetes Care, vol. 13, no. 3, pp. 209-218.
Thorens B, Charron MJ, Lodish HF. Molecular physiology of glucose transporters. Diabetes Care. 1990 Mar;13(3):209-218.
Thorens, Bernard ; Charron, Maureen J. ; Lodish, Harvey F. / Molecular physiology of glucose transporters. In: Diabetes Care. 1990 ; Vol. 13, No. 3. pp. 209-218.
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