Molecular pathology of low grade malignant lymphomas

Howard Ratech

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

During the last ten years the combined efforts of pathologists and molecular biologists have helped define several new lymphoma diagnostic categories. In particular, the recognition of chromosomal translocations which have activated the BCL1 and BCL2 proto-oncogenes have strong associations with specific types of non-Hodgkin's malignant lymphomas such as mantle cell lymphoma and follicular center cell lymphoma, respectively. This review will attempt to summarize our current understanding regarding the contributions of BCL1 and BCL2 to lymphomagenesis and diagnosis.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalMedical Oncology
Volume12
Issue number3
DOIs
StatePublished - Sep 1 1995

Keywords

  • BCL1
  • BCL2
  • DNA
  • follicular lymphoma
  • lymphoma
  • mantle cell lymphoma
  • molecular diagnosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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