Molecular pathology and molecular pharmacology of osteosarcoma

M. Ladanyi, R. Gorlick

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Abnormalities of many tumor suppressor genes and oncogenes have been described in osteosarcoma, but separating early or primary from secondary or late genetic lesions has been difficult. Among early lesions, inactivation of both the P53 and RB pathways appears to be a central and perhaps necessary event in osteosarcomagenesis. We propose a working model for the molecular pathology of osteosarcoma and we review the numerous published studies examining the association of various molecular features with either advanced presentation, poor chemotherapy response or decreased patient survival.

Original languageEnglish (US)
Pages (from-to)391-413
Number of pages23
JournalPediatric Pathology and Molecular Medicine
Volume19
Issue number5
StatePublished - 2000
Externally publishedYes

Fingerprint

Molecular Pathology
Osteosarcoma
Pharmacology
Tumor Suppressor Genes
Oncogenes
Drug Therapy
Survival

Keywords

  • Cyclin dependent kinase (CDK)
  • Retinoblastoma (RB)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Molecular pathology and molecular pharmacology of osteosarcoma. / Ladanyi, M.; Gorlick, R.

In: Pediatric Pathology and Molecular Medicine, Vol. 19, No. 5, 2000, p. 391-413.

Research output: Contribution to journalArticle

Ladanyi, M. ; Gorlick, R. / Molecular pathology and molecular pharmacology of osteosarcoma. In: Pediatric Pathology and Molecular Medicine. 2000 ; Vol. 19, No. 5. pp. 391-413.
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