Molecular mechanisms used by tumors to escape immune recognition

Immunogenetherapy and the cell biology of major histocompatibility complex class I

Nicholas P. Restifo, Yutaka Kawakami, Franco Marincola, Peter Shamamian, Akash Taggarse, Fernando Esquivel, Steven A. Rosenberg

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

In this article, we explore the hypothesis that tumor cells can escape recognition by CD8<inf>+</inf>T cells via deficiencies in antigen processing and presentation. Aspects of the molecular and cellular biology of major histocompatibility complex class I are reviewed. Evidence for histology-specific molecular mechanisms in the antigen-processing and -presentation deficiencies observed in some human and murine tumors is presented. Mechanisms identified include down-regulation of antigen processing, loss of functional β2-microglobulin, and deletion of specific α-chain alleles. Finally, we discuss studies using an antigen-presentation-deficient mouse tumor as a model for the immunogenetherapy of an antigen-presentation deficiency.

Original languageEnglish (US)
Pages (from-to)182-190
Number of pages9
JournalJournal of Immunotherapy
Volume14
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Tumor Escape
Antigen Presentation
Major Histocompatibility Complex
Cell Biology
Neoplasms
Molecular Biology
Histology
Down-Regulation
Alleles
T-Lymphocytes

Keywords

  • Antigen presentation
  • Antigen processing
  • CD8<inf>+</inf>T cells
  • Major histocompatibility complex class I
  • Tumor
  • Vaccinia virus, recombinant

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

Molecular mechanisms used by tumors to escape immune recognition : Immunogenetherapy and the cell biology of major histocompatibility complex class I. / Restifo, Nicholas P.; Kawakami, Yutaka; Marincola, Franco; Shamamian, Peter; Taggarse, Akash; Esquivel, Fernando; Rosenberg, Steven A.

In: Journal of Immunotherapy, Vol. 14, No. 3, 1993, p. 182-190.

Research output: Contribution to journalArticle

Restifo, Nicholas P. ; Kawakami, Yutaka ; Marincola, Franco ; Shamamian, Peter ; Taggarse, Akash ; Esquivel, Fernando ; Rosenberg, Steven A. / Molecular mechanisms used by tumors to escape immune recognition : Immunogenetherapy and the cell biology of major histocompatibility complex class I. In: Journal of Immunotherapy. 1993 ; Vol. 14, No. 3. pp. 182-190.
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