TY - JOUR
T1 - Molecular mechanisms of nonmuscle myosin-II regulation
AU - Bresnick, Anne R.
PY - 1999/2/1
Y1 - 1999/2/1
N2 - Myosin II, the conventional two-headed myosin that forms bipolar filaments, is directly involved in regulating cytokinesis, cell motility and cell morphology in nonmuscle cells. To understand the mechanisms by which nonmuscle myosin-II regulates these processes, investigators are now looking at the regulation of this molecule in vertebrate nonmuscle cells. The identification of multiple isoforms of nonmuscle myosin-II, whose activities and regulation differ from that of smooth muscle myosin-II, suggests that, in addition to regulatory light chain phosphorylation, other regulatory mechanisms control vertebrate nonmuscle myosin-II activity.
AB - Myosin II, the conventional two-headed myosin that forms bipolar filaments, is directly involved in regulating cytokinesis, cell motility and cell morphology in nonmuscle cells. To understand the mechanisms by which nonmuscle myosin-II regulates these processes, investigators are now looking at the regulation of this molecule in vertebrate nonmuscle cells. The identification of multiple isoforms of nonmuscle myosin-II, whose activities and regulation differ from that of smooth muscle myosin-II, suggests that, in addition to regulatory light chain phosphorylation, other regulatory mechanisms control vertebrate nonmuscle myosin-II activity.
UR - http://www.scopus.com/inward/record.url?scp=0033005168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033005168&partnerID=8YFLogxK
U2 - 10.1016/S0955-0674(99)80004-0
DO - 10.1016/S0955-0674(99)80004-0
M3 - Article
C2 - 10047526
AN - SCOPUS:0033005168
SN - 0955-0674
VL - 11
SP - 26
EP - 33
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -