Molecular docking studies of angiogenesis target protein HIF-1α and genistein in breast cancer

Vidya Mukund, Madhu Sudhana Saddala, Batoul Farran, Mastan Mannavarapu, Afroz Alam, Ganji Purnachandra Nagaraju

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Therapeutic inhibition of hypoxia inducible factor-1α (HIF-1α) action has emerged as a potential approach for managing several diseases including breast cancer (BC). Genistein has been found to exert anti-malignant activity. However, its mechanisms of action remain unknown. Studies indicate that it could act by downregulating HIF-1α. Based on these findings, we investigated whether genistein could reduce HIF-1α in BC cell lines. Furthermore, we performed molecular docking studies to characterize the sites of interaction between genistein and HIF-1α. In the present investigation, we prove, for the first time, that genistein downregulates HIF-1α in BC cells. Molecular docking analysis also revealed that genistein binds to the FIH-1 binding site of HIF-1α protein. These findings thus indicate that genistein and/or HIF-1α antagonists could be a potential treatment for BC.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalGene
Volume701
DOIs
StatePublished - Jun 15 2019
Externally publishedYes

Keywords

  • Breast cancer
  • Docking
  • Genistein
  • HIF-1α

ASJC Scopus subject areas

  • Genetics

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