Molecular cloning of the interleukin-1β converting enzyme

Douglas Pat Cerretti, Carl J. Kozlosky, Bruce Mosley, Nicole Nelson, Kirk Van Ness, Teresa A. Greenstreet, Carl J. March, Shirley R. Kronheim, Teresa Druck, Linda A. Cannizzaro, Kay Huebner, Roy A. Black

Research output: Contribution to journalArticlepeer-review

934 Scopus citations

Abstract

Interleukin-1β (IL-1β) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1β to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalScience
Volume256
Issue number5053
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • General

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