Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date

Jayson I.L. Bastien, Katharine A. McNeill, Howard A. Fine

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

During the last decade, extensive multiplatform genome-wide analysis has yielded a wealth of knowledge regarding the genetic and molecular makeup of glioblastoma multiforme (GBM). These profiling studies support the emerging view that GBM comprises a group of highly heterogeneous tumor types, each with its own distinct molecular and genetic signatures. This heterogeneity complicates the process of defining reliable intertumor/intratumor biological states, which will ultimately be needed for classifying tumors and for designing effective customized therapies that target resultant disease pathways. The increased understanding of the molecular pathogenesis of GBM has brought the hope and expectation that such knowledge will lead to better and more rational therapies directed toward specific molecular targets. To date, however, these expectations have largely been unrealized. This review discusses some of the principal genetic and epigenetic aberrations found in GBM that appear promising for targeted therapies now and in the near future, and it offers suggestions for future directions concerning the rather disappointing results of clinical trials to date.

Original languageEnglish (US)
Pages (from-to)502-516
Number of pages15
JournalCancer
Volume121
Issue number4
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

Keywords

  • Clinical trials
  • Epigenetic
  • Genetic
  • Glioblastoma
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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