Models for the initiation and growth of extracellular lipid liposomes in arterial intima and valves

Yongyi Yin, Kwang Hee Lim, Sheldon Weinbaum, Shu Chien, David Rumschitzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A hierarchy of simple nucleation-polymerization models is proposed to describe liposome formation and growth. The cholesterol-fed rabbit intima data seem to result from the short-term nonuniform intimal history of low-density lipoprotein (LDL) supply, which is a consequence of the focal nature of the transarterial-endothelial LDL flow through isolated transient leaky junctions. An appropriate valve water/LDL transport model is combined with the nucleation/polymerization models to explain the data.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
EditorsK.B. Chandran, R. Vanderby, M.S. Hefzy
PublisherASME
Pages91
Number of pages1
Volume35
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 Bioengineering Conference - Sunriver, OR, USA
Duration: Jun 11 1997Jun 15 1997

Other

OtherProceedings of the 1997 Bioengineering Conference
CitySunriver, OR, USA
Period6/11/976/15/97

Fingerprint

Lipoproteins
Liposomes
Lipids
Nucleation
Polymerization
Cholesterol
Water

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Yin, Y., Lim, K. H., Weinbaum, S., Chien, S., & Rumschitzki, D. (1997). Models for the initiation and growth of extracellular lipid liposomes in arterial intima and valves. In K. B. Chandran, R. Vanderby, & M. S. Hefzy (Eds.), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 35, pp. 91). ASME.

Models for the initiation and growth of extracellular lipid liposomes in arterial intima and valves. / Yin, Yongyi; Lim, Kwang Hee; Weinbaum, Sheldon; Chien, Shu; Rumschitzki, David.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. ed. / K.B. Chandran; R. Vanderby; M.S. Hefzy. Vol. 35 ASME, 1997. p. 91.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yin, Y, Lim, KH, Weinbaum, S, Chien, S & Rumschitzki, D 1997, Models for the initiation and growth of extracellular lipid liposomes in arterial intima and valves. in KB Chandran, R Vanderby & MS Hefzy (eds), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 35, ASME, pp. 91, Proceedings of the 1997 Bioengineering Conference, Sunriver, OR, USA, 6/11/97.
Yin Y, Lim KH, Weinbaum S, Chien S, Rumschitzki D. Models for the initiation and growth of extracellular lipid liposomes in arterial intima and valves. In Chandran KB, Vanderby R, Hefzy MS, editors, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 35. ASME. 1997. p. 91
Yin, Yongyi ; Lim, Kwang Hee ; Weinbaum, Sheldon ; Chien, Shu ; Rumschitzki, David. / Models for the initiation and growth of extracellular lipid liposomes in arterial intima and valves. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. editor / K.B. Chandran ; R. Vanderby ; M.S. Hefzy. Vol. 35 ASME, 1997. pp. 91
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