Model-based analysis of matrix metalloproteinase expression under mechanical shear

Hui (Herb) Sun, Yunlong Liu, Lei Qian, Hiroki Yokota

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The development of a model-based analysis for identification of the role of transcription factor (TF) binding motifs was reported. A nonlinear mathematical model was formulated to establish the quantitative relationship between the temporal expression profiles and the distribution of known TF binding motifs on regulatory DNA regions. Using the shear stress responses of a family of matrix metalloproteinases in human synovial cells as a model system, it was shown that the nonlinear formulation was able to approximate the experimentally observed expression profile better than the linear formulation.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalAnnals of Biomedical Engineering
Volume31
Issue number2
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Transcription factors
Shear stress
Identification (control systems)
DNA
Mathematical models
Metalloproteases

Keywords

  • Mathematical model
  • MMP
  • Nonlinear
  • Regulatory DNA elements
  • Stress response
  • Transcription factor

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Model-based analysis of matrix metalloproteinase expression under mechanical shear. / Sun, Hui (Herb); Liu, Yunlong; Qian, Lei; Yokota, Hiroki.

In: Annals of Biomedical Engineering, Vol. 31, No. 2, 2003, p. 171-180.

Research output: Contribution to journalArticle

Sun, Hui (Herb) ; Liu, Yunlong ; Qian, Lei ; Yokota, Hiroki. / Model-based analysis of matrix metalloproteinase expression under mechanical shear. In: Annals of Biomedical Engineering. 2003 ; Vol. 31, No. 2. pp. 171-180.
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