Model-based analysis of matrix metalloproteinase expression under mechanical shear

Hui Bin Sun, Yunlong Liu, Lei Qian, Hiroki Yokota

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The development of a model-based analysis for identification of the role of transcription factor (TF) binding motifs was reported. A nonlinear mathematical model was formulated to establish the quantitative relationship between the temporal expression profiles and the distribution of known TF binding motifs on regulatory DNA regions. Using the shear stress responses of a family of matrix metalloproteinases in human synovial cells as a model system, it was shown that the nonlinear formulation was able to approximate the experimentally observed expression profile better than the linear formulation.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalAnnals of Biomedical Engineering
Volume31
Issue number2
DOIs
Publication statusPublished - Jan 1 2003
Externally publishedYes

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Keywords

  • MMP
  • Mathematical model
  • Nonlinear
  • Regulatory DNA elements
  • Stress response
  • Transcription factor

ASJC Scopus subject areas

  • Biomedical Engineering

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