MNGIE neuropathy: Five cases mimicking chrohic inflammatory demyelinating polyneuropathy

Richard S. Bedlack, Tuan Vu, Simon Hammans, Steven A. Sparr, Bennett Myers, Joel Morgenlander, Michio Hirano

Research output: Contribution to journalArticle

47 Scopus citations


We report five patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) who had demyelinating peripheral neuropathy. The MNGIE neuropathy had clinical and electrodiagnostic features typical of acquired, rather than inherited, etiologies. In fact, three patients were actually treated for chronic inflammatory demyelinating polyneuropathy (CIDP). We discuss findings that may help distinguish patients with MNGIE from those with CIDP.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalMuscle and Nerve
Issue number3
Publication statusPublished - Mar 1 2004



  • Demyelination
  • Inflammation
  • Mitochondria
  • Mitochondrial myopathy
  • Peripheral neuropathy
  • Thymidine phosphorylase

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Bedlack, R. S., Vu, T., Hammans, S., Sparr, S. A., Myers, B., Morgenlander, J., & Hirano, M. (2004). MNGIE neuropathy: Five cases mimicking chrohic inflammatory demyelinating polyneuropathy. Muscle and Nerve, 29(3), 364-368.