Minimally invasive percutaneous pericardial ICD placement in an infant piglet model: Head-to-head comparison with an open surgical thoracotomy approach

Bradley C. Clark, Tanya D. Davis, Magdy M. El-Sayed Ahmed, Robert McCarter, Nobuyuki Ishibashi, Christopher P. Jordan, Timothy D. Kane, Peter C.W. Kim, Axel Krieger, Dilip S. Nath, Justin D. Opfermann, Charles I. Berul

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Epicardial implantable cardioverter-defibrillator (ICD) placement in infants, children, and patients with complex cardiac anatomy requires an open surgical thoracotomy and is associated with increased pain, longer length of stay, and higher cost. Objective The purpose of this study was to compare an open surgical epicardial placement approach with percutaneous pericardial placement of an ICD lead system in an infant piglet model. Methods Animals underwent either epicardial placement by direct suture fixation through a left thoracotomy or minimally invasive pericardial placement with thoracoscopic visualization. Initial lead testing and defibrillation threshold testing (DFT) were performed. After the 2-week survival period, repeat lead testing and DFT were performed before euthanasia. Results Minimally invasive placement was performed in 8 piglets and open surgical placement in 7 piglets without procedural morbidity or mortality. The mean initial DFT value was 10.5 J (range 3-28 J) in the minimally invasive group and 10.0 J (range 5-35 J) in the open surgical group (P =.90). After the survival period, the mean DFT value was 12.0 J (range 3-20 J) in the minimally invasive group and 12.3 J (range 3-35 J) in the open surgical group (P =.95). All lead and shock impedances, R-wave amplitudes, and ventricular pacing thresholds remained stable throughout the survival period. Conclusion Compared with open surgical epicardial ICD lead placement, minimally invasive pericardial placement demonstrates an equivalent ability to effectively defibrillate the heart and has demonstrated similar lead stability. With continued technical development and operator experience, the minimally invasive method may provide a viable alternative to epicardial ICD lead placement in infants, children, and adults at risk of sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)1096-1104
Number of pages9
JournalHeart Rhythm
Volume13
Issue number5
DOIs
StatePublished - May 1 2016
Externally publishedYes

Fingerprint

Implantable Defibrillators
Thoracotomy
Survival
Aptitude
Euthanasia
Sudden Cardiac Death
Electric Impedance
Sutures
Shock
Length of Stay
Anatomy
Lead
Morbidity
Costs and Cost Analysis
Pain
Mortality

Keywords

  • Congenital heart disease
  • Defibrillation threshold testing
  • Implantable cardioverter-defibrillator
  • Minimally invasive
  • Pediatrics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Minimally invasive percutaneous pericardial ICD placement in an infant piglet model : Head-to-head comparison with an open surgical thoracotomy approach. / Clark, Bradley C.; Davis, Tanya D.; El-Sayed Ahmed, Magdy M.; McCarter, Robert; Ishibashi, Nobuyuki; Jordan, Christopher P.; Kane, Timothy D.; Kim, Peter C.W.; Krieger, Axel; Nath, Dilip S.; Opfermann, Justin D.; Berul, Charles I.

In: Heart Rhythm, Vol. 13, No. 5, 01.05.2016, p. 1096-1104.

Research output: Contribution to journalArticle

Clark, BC, Davis, TD, El-Sayed Ahmed, MM, McCarter, R, Ishibashi, N, Jordan, CP, Kane, TD, Kim, PCW, Krieger, A, Nath, DS, Opfermann, JD & Berul, CI 2016, 'Minimally invasive percutaneous pericardial ICD placement in an infant piglet model: Head-to-head comparison with an open surgical thoracotomy approach', Heart Rhythm, vol. 13, no. 5, pp. 1096-1104. https://doi.org/10.1016/j.hrthm.2015.12.015
Clark, Bradley C. ; Davis, Tanya D. ; El-Sayed Ahmed, Magdy M. ; McCarter, Robert ; Ishibashi, Nobuyuki ; Jordan, Christopher P. ; Kane, Timothy D. ; Kim, Peter C.W. ; Krieger, Axel ; Nath, Dilip S. ; Opfermann, Justin D. ; Berul, Charles I. / Minimally invasive percutaneous pericardial ICD placement in an infant piglet model : Head-to-head comparison with an open surgical thoracotomy approach. In: Heart Rhythm. 2016 ; Vol. 13, No. 5. pp. 1096-1104.
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abstract = "Background Epicardial implantable cardioverter-defibrillator (ICD) placement in infants, children, and patients with complex cardiac anatomy requires an open surgical thoracotomy and is associated with increased pain, longer length of stay, and higher cost. Objective The purpose of this study was to compare an open surgical epicardial placement approach with percutaneous pericardial placement of an ICD lead system in an infant piglet model. Methods Animals underwent either epicardial placement by direct suture fixation through a left thoracotomy or minimally invasive pericardial placement with thoracoscopic visualization. Initial lead testing and defibrillation threshold testing (DFT) were performed. After the 2-week survival period, repeat lead testing and DFT were performed before euthanasia. Results Minimally invasive placement was performed in 8 piglets and open surgical placement in 7 piglets without procedural morbidity or mortality. The mean initial DFT value was 10.5 J (range 3-28 J) in the minimally invasive group and 10.0 J (range 5-35 J) in the open surgical group (P =.90). After the survival period, the mean DFT value was 12.0 J (range 3-20 J) in the minimally invasive group and 12.3 J (range 3-35 J) in the open surgical group (P =.95). All lead and shock impedances, R-wave amplitudes, and ventricular pacing thresholds remained stable throughout the survival period. Conclusion Compared with open surgical epicardial ICD lead placement, minimally invasive pericardial placement demonstrates an equivalent ability to effectively defibrillate the heart and has demonstrated similar lead stability. With continued technical development and operator experience, the minimally invasive method may provide a viable alternative to epicardial ICD lead placement in infants, children, and adults at risk of sudden cardiac death.",
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T2 - Head-to-head comparison with an open surgical thoracotomy approach

AU - Clark, Bradley C.

AU - Davis, Tanya D.

AU - El-Sayed Ahmed, Magdy M.

AU - McCarter, Robert

AU - Ishibashi, Nobuyuki

AU - Jordan, Christopher P.

AU - Kane, Timothy D.

AU - Kim, Peter C.W.

AU - Krieger, Axel

AU - Nath, Dilip S.

AU - Opfermann, Justin D.

AU - Berul, Charles I.

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N2 - Background Epicardial implantable cardioverter-defibrillator (ICD) placement in infants, children, and patients with complex cardiac anatomy requires an open surgical thoracotomy and is associated with increased pain, longer length of stay, and higher cost. Objective The purpose of this study was to compare an open surgical epicardial placement approach with percutaneous pericardial placement of an ICD lead system in an infant piglet model. Methods Animals underwent either epicardial placement by direct suture fixation through a left thoracotomy or minimally invasive pericardial placement with thoracoscopic visualization. Initial lead testing and defibrillation threshold testing (DFT) were performed. After the 2-week survival period, repeat lead testing and DFT were performed before euthanasia. Results Minimally invasive placement was performed in 8 piglets and open surgical placement in 7 piglets without procedural morbidity or mortality. The mean initial DFT value was 10.5 J (range 3-28 J) in the minimally invasive group and 10.0 J (range 5-35 J) in the open surgical group (P =.90). After the survival period, the mean DFT value was 12.0 J (range 3-20 J) in the minimally invasive group and 12.3 J (range 3-35 J) in the open surgical group (P =.95). All lead and shock impedances, R-wave amplitudes, and ventricular pacing thresholds remained stable throughout the survival period. Conclusion Compared with open surgical epicardial ICD lead placement, minimally invasive pericardial placement demonstrates an equivalent ability to effectively defibrillate the heart and has demonstrated similar lead stability. With continued technical development and operator experience, the minimally invasive method may provide a viable alternative to epicardial ICD lead placement in infants, children, and adults at risk of sudden cardiac death.

AB - Background Epicardial implantable cardioverter-defibrillator (ICD) placement in infants, children, and patients with complex cardiac anatomy requires an open surgical thoracotomy and is associated with increased pain, longer length of stay, and higher cost. Objective The purpose of this study was to compare an open surgical epicardial placement approach with percutaneous pericardial placement of an ICD lead system in an infant piglet model. Methods Animals underwent either epicardial placement by direct suture fixation through a left thoracotomy or minimally invasive pericardial placement with thoracoscopic visualization. Initial lead testing and defibrillation threshold testing (DFT) were performed. After the 2-week survival period, repeat lead testing and DFT were performed before euthanasia. Results Minimally invasive placement was performed in 8 piglets and open surgical placement in 7 piglets without procedural morbidity or mortality. The mean initial DFT value was 10.5 J (range 3-28 J) in the minimally invasive group and 10.0 J (range 5-35 J) in the open surgical group (P =.90). After the survival period, the mean DFT value was 12.0 J (range 3-20 J) in the minimally invasive group and 12.3 J (range 3-35 J) in the open surgical group (P =.95). All lead and shock impedances, R-wave amplitudes, and ventricular pacing thresholds remained stable throughout the survival period. Conclusion Compared with open surgical epicardial ICD lead placement, minimally invasive pericardial placement demonstrates an equivalent ability to effectively defibrillate the heart and has demonstrated similar lead stability. With continued technical development and operator experience, the minimally invasive method may provide a viable alternative to epicardial ICD lead placement in infants, children, and adults at risk of sudden cardiac death.

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