Minimally-invasive device-based approaches for improving cardiac perfusion

Gramegna Mario, Ponticelli Francesco, Baldetti Luca, Gallone Guglielmo, Regazzoli Damiano, Giannini Francesco, Latib Azeem

Research output: Chapter in Book/Report/Conference proceedingChapter


Improvements in medical therapy and coronary revascularization have led to an increased survival rate in patients with coronary artery disease (CAD), with a consequent growing number of patients with severe and diffuse CAD which is not amenable to further revascularization procedures. The majority of these patients have either angina pectoris refractory to optimal medical therapy or chronic heart failure symptoms. While the goal of therapy in refractory angina pectoris patients should mostly be directed at improving patients’ symptoms and quality of life, therapy in severe diffuse CAD should be focused on myocardial ischemia reduction and survival improvement. In recent years, a number of innovative non-pharmacological therapeutic options, aimed at improving angina symptoms and quality of life by reducing myocardial ischemia, have been investigated in this challenging patient group. We summarize the different non-pharmacological therapeutic options that are available or are under development, aimed at improving myocardial perfusion in patients with proven myocardial ischemia and CAD not amenable to further revascularization.

Original languageEnglish (US)
Title of host publicationEmerging Technologies for Heart Diseases
Subtitle of host publicationVolume 2: Treatments for Myocardial Ischemia and Arrhythmias
Number of pages25
ISBN (Electronic)9780128137048
StatePublished - Jan 1 2020


  • Chronic heart failure
  • Coronary artery disease
  • Myocardial perfusion
  • Non-pharmacological therapies
  • Refractory angina pectoris

ASJC Scopus subject areas

  • Medicine(all)


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