Migraine History, Nonsteroidal Anti-inflammatory Drug Use, and Risk of Postmenopausal Endometrial Cancer

Amanda I. Phipps, Garnet L. Anderson, Barbara B. Cochrane, Christopher I. Li, Jean Wactawski-Wende, Gloria Y F Ho, Mary Jo O'Sullivan, Polly A. Newcomb

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Endometrial cancer is primarily a hormonally mediated disease. As such, factors that mediate or reflect exposure to estrogens, or that mediate response to such exposure, may plausibly be associated with endometrial cancer risk. History of migraines, another hormonally mediated condition, has recently been associated with a reduced risk of hormone receptor-positive breast cancer; however, the relationship between migraines and endometrial cancer has not previously been explored. We evaluated the relationship between migraine history and endometrial cancer risk in postmenopausal women, considering also the potential impact of nonsteroidal anti-inflammatory drug (NSAID) use, given the relationship of NSAIDs to hormones and to migraine history. We identified 93,384 women participating in the Women's Health Initiative prospective cohort who had an intact uterus at the time of study entry. Using Cox proportional hazards regression, we assessed risk of endometrial cancer during study follow-up according to history of migraines and according to current NSAID use at the time of study entry, adjusting for age, study arm, race, and hormone therapy use. We also evaluated interaction in these associations by body mass index. Having a history of migraines was not associated with endometrial cancer risk [hazard ratio (HR) = 0.91, 95% confidence interval (CI) = 0.75-1.11], regardless of body mass index (BMI) or NSAID use status. Similarly, current NSAID use was not associated with endometrial cancer risk (HR = 1. 01, 95% CI = 0. 88-1.16), regardless of BMI. Migraine history and NSAID use do not appear to be associated with risk of endometrial cancer.

Original languageEnglish (US)
Pages (from-to)240-248
Number of pages9
JournalHormones and Cancer
Volume3
Issue number5-6
DOIs
StatePublished - 2012

Fingerprint

Endometrial Neoplasms
Migraine Disorders
Anti-Inflammatory Agents
Pharmaceutical Preparations
Body Mass Index
Time and Motion Studies
Hormones
Odds Ratio
Confidence Intervals
Women's Health
Non-Steroidal Anti-Inflammatory Agents
Uterus
Estrogens
Breast Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

Cite this

Phipps, A. I., Anderson, G. L., Cochrane, B. B., Li, C. I., Wactawski-Wende, J., Ho, G. Y. F., ... Newcomb, P. A. (2012). Migraine History, Nonsteroidal Anti-inflammatory Drug Use, and Risk of Postmenopausal Endometrial Cancer. Hormones and Cancer, 3(5-6), 240-248. https://doi.org/10.1007/s12672-012-0117-7

Migraine History, Nonsteroidal Anti-inflammatory Drug Use, and Risk of Postmenopausal Endometrial Cancer. / Phipps, Amanda I.; Anderson, Garnet L.; Cochrane, Barbara B.; Li, Christopher I.; Wactawski-Wende, Jean; Ho, Gloria Y F; O'Sullivan, Mary Jo; Newcomb, Polly A.

In: Hormones and Cancer, Vol. 3, No. 5-6, 2012, p. 240-248.

Research output: Contribution to journalArticle

Phipps, AI, Anderson, GL, Cochrane, BB, Li, CI, Wactawski-Wende, J, Ho, GYF, O'Sullivan, MJ & Newcomb, PA 2012, 'Migraine History, Nonsteroidal Anti-inflammatory Drug Use, and Risk of Postmenopausal Endometrial Cancer', Hormones and Cancer, vol. 3, no. 5-6, pp. 240-248. https://doi.org/10.1007/s12672-012-0117-7
Phipps, Amanda I. ; Anderson, Garnet L. ; Cochrane, Barbara B. ; Li, Christopher I. ; Wactawski-Wende, Jean ; Ho, Gloria Y F ; O'Sullivan, Mary Jo ; Newcomb, Polly A. / Migraine History, Nonsteroidal Anti-inflammatory Drug Use, and Risk of Postmenopausal Endometrial Cancer. In: Hormones and Cancer. 2012 ; Vol. 3, No. 5-6. pp. 240-248.
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