microRNAs distinctively regulate vascular smooth muscle and endothelial cells: Functional implications in angiogenesis, atherosclerosis, and in-stent restenosis

Gaetano Santulli

Research output: Chapter in Book/Report/Conference proceedingChapter

50 Scopus citations

Abstract

Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are the main cell types within the vasculature. We describe here how microRNAs (miRs)— noncoding RNAs that can regulate gene expression via translational repression and/ or post-transcriptional degradation—distinctively modulate EC and VSMC function in physiology and disease. In particular, the specifi c roles of miR-126 and miR- 143/145, master regulators of EC and VSMC function, respectively, are deeply explored. We also describe the mechanistic role of miRs in the regulation of the pathophysiology of key cardiovascular processes including angiogenesis, atherosclerosis, and in-stent restenosis post-angioplasty. Drawbacks of currently available therapeutic options are discussed, pointing at the challenges and potential clinical opportunities provided by miR-based treatments.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages53-77
Number of pages25
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume887
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Angiogenesis
  • Angioplasty
  • Atherosclerosis
  • Circulation
  • DES
  • Diabetes
  • Endothelium
  • Inflammation
  • miR-126
  • miR-143/145
  • Myocardin
  • Myoregulin
  • Neointima
  • Restenosis
  • Stent
  • Thrombosis
  • VSMC

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Santulli, G. (2015). microRNAs distinctively regulate vascular smooth muscle and endothelial cells: Functional implications in angiogenesis, atherosclerosis, and in-stent restenosis. In Advances in Experimental Medicine and Biology (pp. 53-77). (Advances in Experimental Medicine and Biology; Vol. 887). Springer New York LLC. https://doi.org/10.1007/978-3-319-22380-3_4