MicroRNAs and Endothelial (Dys) Function

Gaetano Santulli

Research output: Contribution to journalShort survey

65 Scopus citations

Abstract

Accumulating evidence indicates that microRNAs (miRs)-non-coding RNAs that can regulate gene expression via translational repression and/or post-transcriptional degradation-are becoming one of the most fascinating areas of physiology, given their fundamental roles in countless pathophysiological processes. The relative roles of different miRs in vascular biology as direct or indirect post-transcriptional regulators of fundamental genes implied in vascular remodeling designate miRs as potential biomarkers and/or promising drug targets. The mechanistic importance of miRs in modulating endothelial cell (EC) function in physiology and in disease is addressed here. Drawbacks of currently available therapeutic options are also discussed, pointing at the challenges and clinical opportunities provided by miR-based treatments.

Original languageEnglish (US)
Pages (from-to)1638-1644
Number of pages7
JournalJournal of Cellular Physiology
Volume231
Issue number8
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'MicroRNAs and Endothelial (Dys) Function'. Together they form a unique fingerprint.

  • Cite this