Abstract
Mice transgenic for many copies of the human wild type transthyretin gene were bred and maintained in a specific pathogen free environment until twelve months of age. At that time, half the animals were moved to a conventional animal facility. The incidence of both transthyretin and AA amyloid was the same in both groups at two years of age, indicating that in this model, the frequency, extent or nature of TTR-amyloid deposition did not differ significantly between conventional and specific pathogen-free environments.
Original language | English (US) |
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Pages (from-to) | 262-266 |
Number of pages | 5 |
Journal | Amyloid |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2003 |
Externally published | Yes |
Keywords
- Amyloidosis
- Specific pathogen-free
- TTR environment
- Transgenic
ASJC Scopus subject areas
- Internal Medicine