@article{8f7da7cf55014572b8c6f0e0cae3ce2c,
title = "Methodologic recommendations and possible interpretations of video-EEG recordings in immature rodents used as experimental controls: A TASK1-WG2 report of the ILAE/AES Joint Translational Task Force",
abstract = "The use of immature rodents to study physiologic aspects of cortical development requires high-quality recordings electroencephalography (EEG) with simultaneous video recording (vEEG) of behavior. Normative developmental vEEG data in control animals are fundamental for the study of abnormal background activity in animal models of seizures or other neurologic disorders. Electrical recordings from immature, freely behaving rodents can be particularly difficult because of the small size of immature rodents, their thin and soft skull, interference with the recording apparatus by the dam, and other technical challenges. In this report of the TASK1 Working Group 2 (WG2) of the International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force, we provide suggestions that aim to optimize future vEEG recordings from immature rodents, as well as their interpretation. We focus on recordings from immature rodents younger than 30 days old used as experimental controls, because the quality and correct interpretation of such recordings is important when interpreting the vEEG results of animals serving as models of neurologic disorders. We discuss the technical aspects of such recordings and compare tethered versus wireless approaches. We also summarize the appearance of common artifacts and various patterns of electrical activity seen in young rodents used as controls as a function of behavioral state, age, and (where known) sex and strain. The information herein will hopefully help improve the methodology of vEEG recordings from immature rodents and may lead to results and interpretations that are more consistent across studies from different laboratories.",
keywords = "Anesthesia, Awake, Cortical, Minimum standards, Mouse, Ontogeny, Postnatal, Rat, Sleep, Spectral analysis, Spindles, Stereotaxic, Subcortical, vEEG",
author = "Ozlem Akman and Raol, {Yogendra H.} and St{\'e}phane Auvin and Cortez, {Miguel A.} and Hana Kubova and {de Curtis}, Marco and Akio Ikeda and Dudek, {F. Edward} and Galanopoulou, {Aristea S.}",
note = "Funding Information: We are grateful to the AES and ILAE for partial sponsoring the activities of the ILAE/AES Joint Translational Task Force. The authors have received partial travel reimbursement to attend some of the meetings of the TASK1 group of the ILAE/AES Joint Translational Task Force through the AES and the ILAE. The authors are grateful to Dr. Lauren Harte-Hargrove for assistance during the preparation of this manuscript. FED would also like to acknowledge assistance from Jeff Bastar, Erika Scholl, Vicki Skelton, and Andrew Zayachkivsky. YHR: acknowledges grant support from grant NIH/NICHD R01 HD065534. SA acknowledges grant support by INSERM, Association INJENO, Association Lily-Rose & Association “Kemil et Ses Amis.” MAC received financial research support from EpLink - The Epilepsy Research Program of the Ontario Brain Institute (OBI), The Hospital for Sick Children Foundation, and the Canadian Institutes of Health Research, CIHR No. 232232). HK acknowledges grants from the Czech Science Foundation (Grant Numnber 16-04726S), the European Regional Development Fund-Projects “PharmaBrain” No. CZ.CZ.02.1.01/0.0/0.0/16_025/0007444, the Ministry of Education (Grant Number LH 15025), and support for long-term conceptual development of research organization RVO: 67985823. AI acknowledges the grants by MEXT, KAKENHI Grant Numbers 15H05874. FED acknowledges research support from grants and contracts from NINDS and the United States Department of Defense. ASG acknowledges grant support by NINDS R01 NS091170, U54 NS100064, the United States Department of Defense (W81XWH-13-1-0180), the CURE Infantile Spasms Initiative, research funding from the Heffer Family, the Segal Family Foundations, and the Abbe Goldstein/Joshua Lurie and Laurie Marsh/Dan Levitz families. Publisher Copyright: {\textcopyright} 2018 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy.",
year = "2018",
month = dec,
doi = "10.1002/epi4.12262",
language = "English (US)",
volume = "3",
pages = "437--459",
journal = "Epilepsia Open",
issn = "2470-9239",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "4",
}