Metformin as a Tool to Target Aging

Nir Barzilai; Jill P. Crandall; Stephen B. Kritchevsky; Mark A. Espeland

doi:10.1016/j.cmet.2016.05.011

Metformin as a Tool to Target Aging

Nir Barzilai, Jill P. Crandall, Stephen B. Kritchevsky, Mark A. Espeland

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

675 Scopus citations

Abstract

Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

Original language	English (US)
Pages (from-to)	1060-1065
Number of pages	6
Journal	Cell metabolism
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2016.05.011
State	Published - Jun 14 2016

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2016.05.011

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title = "Metformin as a Tool to Target Aging",

abstract = "Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.",

author = "Nir Barzilai and Crandall, {Jill P.} and Kritchevsky, {Stephen B.} and Espeland, {Mark A.}",

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AU - Kritchevsky, Stephen B.

AU - Espeland, Mark A.

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Y1 - 2016/6/14

N2 - Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

AB - Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

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Metformin as a Tool to Target Aging

Abstract

ASJC Scopus subject areas

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