@article{18b672eaeefe4751a5826b4f8df52b2f,
title = "Metformin as a Tool to Target Aging",
abstract = "Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.",
author = "Nir Barzilai and Crandall, {Jill P.} and Kritchevsky, {Stephen B.} and Espeland, {Mark A.}",
note = "Funding Information: The American Federation for Aging Research has supported the TAME initiative. This work was supported by the Nathan Shock Center of Excellence for the Biology of Aging (P30AG038072, N.B.), the Glenn Center for the Biology of Human Aging (Paul Glenn Foundation for Medical Research) (N.B.), grant 1R24AG044396 from the National Institute on Aging (NIA) (PI, Kirkland; co-PI, N.B.), and grant P30 AG021332 from the NIA to the Wake Forest Older Americans Independence Center (S.B.K.). Publisher Copyright: {\textcopyright} 2016 Published by Elsevier Inc.",
year = "2016",
month = jun,
day = "14",
doi = "10.1016/j.cmet.2016.05.011",
language = "English (US)",
volume = "23",
pages = "1060--1065",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",
}