Metformin as a Tool to Target Aging

Nir Barzilai, Jill P. Crandall, Stephen B. Kritchevsky, Mark A. Espeland

Research output: Contribution to journalReview article

245 Scopus citations

Abstract

Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

Original languageEnglish (US)
Pages (from-to)1060-1065
Number of pages6
JournalCell Metabolism
Volume23
Issue number6
DOIs
StatePublished - Jun 14 2016

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ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

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