Metastatic Carcinoma

An Unusual Cause of Focal Brain Lesions in HIV Infection

Anu G. Gaba, Joseph A. Sparano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The most common causes of focal brain lesions (FBLS) in patients with HIV infection are cerebral toxoplasmosis, primary central nervous system lymphoma (PCNSL), and progressive multifocal leukoencephalopathy. Neoplasms other than PCNSL are uncommon. We report a rare case of metastatic carcinoma causing an FBL in a patient with HIV infection. The diagnostic workup and further management of FBLs in HIV are outlined in this review. The standard approach includes a lumbar puncture and cerebrospinal fluid (CSF) analysis for cytology and Epstein-Barr virus (EBV) DNA testing by polymerase chain reaction. Empiric therapy for PCNSL is justifiable for patients with positive CSF EBV-DNA test results and a positive single-photon emission computed tomography (SPECT) scan, especially if there has been no response to antitoxoplasmosis therapy. Brain biopsy may be indicated, however, in select cases that do not meet these criteria in order to identify potentially treatable infections and PCNSL.

Original languageEnglish (US)
Pages (from-to)547-548+551
JournalAIDS Reader
Volume13
Issue number11
StatePublished - Nov 2003

Fingerprint

HIV Infections
Lymphoma
Carcinoma
Brain
Cerebrospinal Fluid
Central Nervous System
Cerebral Toxoplasmosis
Progressive Multifocal Leukoencephalopathy
Central Nervous System Infections
Central Nervous System Neoplasms
Spinal Puncture
Single-Photon Emission-Computed Tomography
Human Herpesvirus 4
Cell Biology
HIV
Biopsy
Polymerase Chain Reaction
DNA
Therapeutics

Keywords

  • Cancer
  • Focal brain lesions
  • HIV/AIDS
  • Primary CNS lymphoma

ASJC Scopus subject areas

  • Virology
  • Medicine(all)

Cite this

Metastatic Carcinoma : An Unusual Cause of Focal Brain Lesions in HIV Infection. / Gaba, Anu G.; Sparano, Joseph A.

In: AIDS Reader, Vol. 13, No. 11, 11.2003, p. 547-548+551.

Research output: Contribution to journalArticle

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