Metallocarboxypeptidase Z is dynamically expressed in mouse development

Elena Novikova; Lloyd D. Fricker; Sandra E. Reznik

doi:10.1016/S0925-4773(01)00306-9

Metallocarboxypeptidase Z is dynamically expressed in mouse development

Elena Novikova, Lloyd D. Fricker, Sandra E. Reznik

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Metallocarboxypeptidase Z (CPZ), a new member of the regulatory metallocarboxypeptidases, contains a 120-residue cysteine-rich region that has 20-35% amino acid sequence identity to Drosophila and mammalian frizzled proteins. In order to gain insights into the function of CPZ, we have examined the distribution of the protein by immunohistochemistry throughout mouse development. The expression of CPZ peaks at E9-E12, decreases in late gestation and falls further in adult tissues. CPZ expression in amnion cells, cochlear epithelial cells and surrounding mesenchyme, ventricular lining cells in the brain and cartilagenous condensations and surrounding connective tissue in ribs remains at high levels throughout mouse gestation. The expression pattern of CPZ overlaps with the expression pattern of several Wnt genes, consistent with the putative role of CPZ in Wnt signaling.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Mechanisms of Development
Volume	102
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(01)00306-9
State	Published - 2001

Keywords

Carboxypeptidase Z
Frizzled
Mouse embryo
Wnt

ASJC Scopus subject areas

Embryology
Developmental Biology

Access to Document

10.1016/S0925-4773(01)00306-9

Cite this

@article{f89a925ed16e40219eee2fcefece17a6,

title = "Metallocarboxypeptidase Z is dynamically expressed in mouse development",

abstract = "Metallocarboxypeptidase Z (CPZ), a new member of the regulatory metallocarboxypeptidases, contains a 120-residue cysteine-rich region that has 20-35% amino acid sequence identity to Drosophila and mammalian frizzled proteins. In order to gain insights into the function of CPZ, we have examined the distribution of the protein by immunohistochemistry throughout mouse development. The expression of CPZ peaks at E9-E12, decreases in late gestation and falls further in adult tissues. CPZ expression in amnion cells, cochlear epithelial cells and surrounding mesenchyme, ventricular lining cells in the brain and cartilagenous condensations and surrounding connective tissue in ribs remains at high levels throughout mouse gestation. The expression pattern of CPZ overlaps with the expression pattern of several Wnt genes, consistent with the putative role of CPZ in Wnt signaling.",

keywords = "Carboxypeptidase Z, Frizzled, Mouse embryo, Wnt",

author = "Elena Novikova and Fricker, {Lloyd D.} and Reznik, {Sandra E.}",

note = "Funding Information: This study was supported by National Institutes of Health Grants 1K08HD01209 (to S.E.R.) and K02DA00194 and R01DA04494 (to L.D.F.).",

year = "2001",

doi = "10.1016/S0925-4773(01)00306-9",

language = "English (US)",

volume = "102",

pages = "259--262",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Metallocarboxypeptidase Z is dynamically expressed in mouse development

AU - Novikova, Elena

AU - Fricker, Lloyd D.

AU - Reznik, Sandra E.

N1 - Funding Information: This study was supported by National Institutes of Health Grants 1K08HD01209 (to S.E.R.) and K02DA00194 and R01DA04494 (to L.D.F.).

PY - 2001

Y1 - 2001

N2 - Metallocarboxypeptidase Z (CPZ), a new member of the regulatory metallocarboxypeptidases, contains a 120-residue cysteine-rich region that has 20-35% amino acid sequence identity to Drosophila and mammalian frizzled proteins. In order to gain insights into the function of CPZ, we have examined the distribution of the protein by immunohistochemistry throughout mouse development. The expression of CPZ peaks at E9-E12, decreases in late gestation and falls further in adult tissues. CPZ expression in amnion cells, cochlear epithelial cells and surrounding mesenchyme, ventricular lining cells in the brain and cartilagenous condensations and surrounding connective tissue in ribs remains at high levels throughout mouse gestation. The expression pattern of CPZ overlaps with the expression pattern of several Wnt genes, consistent with the putative role of CPZ in Wnt signaling.

AB - Metallocarboxypeptidase Z (CPZ), a new member of the regulatory metallocarboxypeptidases, contains a 120-residue cysteine-rich region that has 20-35% amino acid sequence identity to Drosophila and mammalian frizzled proteins. In order to gain insights into the function of CPZ, we have examined the distribution of the protein by immunohistochemistry throughout mouse development. The expression of CPZ peaks at E9-E12, decreases in late gestation and falls further in adult tissues. CPZ expression in amnion cells, cochlear epithelial cells and surrounding mesenchyme, ventricular lining cells in the brain and cartilagenous condensations and surrounding connective tissue in ribs remains at high levels throughout mouse gestation. The expression pattern of CPZ overlaps with the expression pattern of several Wnt genes, consistent with the putative role of CPZ in Wnt signaling.

KW - Carboxypeptidase Z

KW - Frizzled

KW - Mouse embryo

KW - Wnt

UR - http://www.scopus.com/inward/record.url?scp=0035062162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035062162&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(01)00306-9

DO - 10.1016/S0925-4773(01)00306-9

M3 - Article

C2 - 11287206

AN - SCOPUS:0035062162

SN - 0925-4773

VL - 102

SP - 259

EP - 262

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1-2

ER -

Metallocarboxypeptidase Z is dynamically expressed in mouse development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this