Metallocarboxypeptidase Z is dynamically expressed in mouse development

Elena Novikova, Lloyd D. Fricker, Sandra E. Reznik

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Metallocarboxypeptidase Z (CPZ), a new member of the regulatory metallocarboxypeptidases, contains a 120-residue cysteine-rich region that has 20-35% amino acid sequence identity to Drosophila and mammalian frizzled proteins. In order to gain insights into the function of CPZ, we have examined the distribution of the protein by immunohistochemistry throughout mouse development. The expression of CPZ peaks at E9-E12, decreases in late gestation and falls further in adult tissues. CPZ expression in amnion cells, cochlear epithelial cells and surrounding mesenchyme, ventricular lining cells in the brain and cartilagenous condensations and surrounding connective tissue in ribs remains at high levels throughout mouse gestation. The expression pattern of CPZ overlaps with the expression pattern of several Wnt genes, consistent with the putative role of CPZ in Wnt signaling.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalMechanisms of Development
Volume102
Issue number1-2
DOIs
StatePublished - 2001

Fingerprint

Pregnancy
Amnion
Cochlea
Ribs
Mesoderm
Connective Tissue
Cysteine
Amino Acid Sequence
Epithelial Cells
Immunohistochemistry
Brain
Genes
Proteins
metallocarboxypeptidase Z
Drosophila fz protein

Keywords

  • Carboxypeptidase Z
  • Frizzled
  • Mouse embryo
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Metallocarboxypeptidase Z is dynamically expressed in mouse development. / Novikova, Elena; Fricker, Lloyd D.; Reznik, Sandra E.

In: Mechanisms of Development, Vol. 102, No. 1-2, 2001, p. 259-262.

Research output: Contribution to journalArticle

Novikova, Elena ; Fricker, Lloyd D. ; Reznik, Sandra E. / Metallocarboxypeptidase Z is dynamically expressed in mouse development. In: Mechanisms of Development. 2001 ; Vol. 102, No. 1-2. pp. 259-262.
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