Metal-induced neurodegeneration in C. elegans

Pan Chen, Ebany J. Martinez-Finley, Julia Bornhorst, Sudipta Chakraborty, Michael Aschner

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The model species, Caenorhabditis elegans, has been used as a tool to probe for mechanisms underlying numerous neurodegenerative diseases. This use has been exploited to study neurodegeneration induced by metals. The allure of the nematode comes from the ease of genetic manipulation, the ability to fluorescently label neuronal subtypes, and the relative simplicity of the nervous system. Notably, C. elegans have approximately 60-80% of human genes and contain genes involved in metal homeostasis and transport, allowing for the study of metal-induced degeneration in the nematode. This review discusses methods to assess degeneration as well as outlines techniques for genetic manipulation and presents a comprehensive survey of the existing literature on metal-induced degeneration studies in the worm.

Original languageEnglish (US)
Article numberArticle 18
JournalFrontiers in Aging Neuroscience
Volume5
Issue numberMAY
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Metals
Caenorhabditis elegans
Genetic Techniques
Neurodegenerative Diseases
Nervous System
Genes
Homeostasis

Keywords

  • Behavior
  • C. elegans
  • Metals
  • Neurodegeneration
  • Neurotransmitters

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

Cite this

Metal-induced neurodegeneration in C. elegans. / Chen, Pan; Martinez-Finley, Ebany J.; Bornhorst, Julia; Chakraborty, Sudipta; Aschner, Michael.

In: Frontiers in Aging Neuroscience, Vol. 5, No. MAY, Article 18, 2013.

Research output: Contribution to journalArticle

Chen, P, Martinez-Finley, EJ, Bornhorst, J, Chakraborty, S & Aschner, M 2013, 'Metal-induced neurodegeneration in C. elegans', Frontiers in Aging Neuroscience, vol. 5, no. MAY, Article 18. https://doi.org/10.3389/fnagi.2013.00018
Chen, Pan ; Martinez-Finley, Ebany J. ; Bornhorst, Julia ; Chakraborty, Sudipta ; Aschner, Michael. / Metal-induced neurodegeneration in C. elegans. In: Frontiers in Aging Neuroscience. 2013 ; Vol. 5, No. MAY.
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