Metal-induced neurodegeneration in C. elegans

Pan Chen, Ebany J. Martinez-Finley, Julia Bornhorst, Sudipta Chakraborty, Michael Aschner

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

The model species, Caenorhabditis elegans, has been used as a tool to probe for mechanisms underlying numerous neurodegenerative diseases. This use has been exploited to study neurodegeneration induced by metals. The allure of the nematode comes from the ease of genetic manipulation, the ability to fluorescently label neuronal subtypes, and the relative simplicity of the nervous system. Notably, C. elegans have approximately 60-80% of human genes and contain genes involved in metal homeostasis and transport, allowing for the study of metal-induced degeneration in the nematode. This review discusses methods to assess degeneration as well as outlines techniques for genetic manipulation and presents a comprehensive survey of the existing literature on metal-induced degeneration studies in the worm.

Original languageEnglish (US)
Article numberArticle 18
JournalFrontiers in Aging Neuroscience
Volume5
Issue numberMAY
DOIs
StatePublished - Sep 11 2013
Externally publishedYes

Keywords

  • Behavior
  • C. elegans
  • Metals
  • Neurodegeneration
  • Neurotransmitters

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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