Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress

Yan Ni, Mingming Su, Jinchao Lin, Xiaoyan Wang, Yunping Qiu, Aihua Zhao, Tianlu Chen, Wei Jia

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

Chronic stress is closely linked to clinical depression, which could be assessed by a chronic unpredictable mild stress (CUMS) animal model. We present here a GC/MS-based metabolic profiling approach to investigate neurochemical changes in the cerebral cortex, hippocampus, thalamus, and remaining brain tissues. Multi-criteria assessment for multivariate statistics could identify differential metabolites between the CUMS-model rats versus the healthy controls. This study demonstrates that the significantly perturbed metabolites mainly involving amino acids play an indispensable role in regulating neural activity in the brain. Therefore, results obtained from such metabolic profiling strategy potentially provide a unique perspective on molecular mechanisms of chronic stress.

Original languageEnglish (US)
Pages (from-to)2627-2636
Number of pages10
JournalFEBS Letters
Volume582
Issue number17
DOIs
StatePublished - Jul 23 2008
Externally publishedYes

Keywords

  • Amino acid
  • Chronic unpredictable mild stress
  • GC/MS
  • Metabolic profiling
  • Multi-criteria assessment
  • Multivariate statistics

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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