Meta-analysis: Drawing conclusions when study results vary

Leslie Rosenthal, Enrique Schisterman

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Low-dose aspirin has been suggested to positively impact a number of clinical outcomes associated with oxidative stress; however, results of clinical trials surrounding its effect on a woman's ability to achieve and sustain pregnancy have been inconclusive. A meta-analysis is an advantageous tool in this situation. Meta-analyses allow researchers to formally and systematically pool together all relevant research in order to clarify findings and form conclusions based on all currently available information. The purpose of this chapter is to describe how to perform a meta-analysis, clarify the impact of model selection, and provide examples of implementation.

Original languageEnglish (US)
Title of host publicationAdvanced Protocols in Oxidative Stress II
PublisherHumana Press Inc.
Pages427-434
Number of pages8
ISBN (Print)9781607614104
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume594
ISSN (Print)1064-3745

Keywords

  • Fixed-effects model
  • Low dose aspirin
  • Meta-analysis
  • Oxidative stress
  • Random-effects model

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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