Mercury

Mingwei Ni; Xin Li; Ana Paula Marreilha dos Santos; Marcelo Farina; João Batista Teixeira da Rocha; Daiana S. Avila; Offie P. Soldin; Lu Rongzhu; Dejan Milatovic; Michael Aschner

doi:10.1016/B978-0-323-89773-0.00030-8

Mercury

Mingwei Ni, Xin Li, Ana Paula Marreilha dos Santos, Marcelo Farina, João Batista Teixeira da Rocha, Daiana S. Avila, Offie P. Soldin, Lu Rongzhu, Dejan Milatovic, Michael Aschner

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Methylmercury (MeHg), an organomercurial, is one of the most prevalent and toxic environmental pollutants. The major route of human exposure occurs via consumption of MeHg-adulterated seafood. Historically, MeHg epidemics in Minamata Bay, Japan, and in Iraq provided evidence of its developmental toxicity and neurological damage. This chapter describes MeHg kinetics in the human body and focuses predominantly on mechanisms involved in neuropathological and reproductive effects. The chapter also discusses the differential susceptibility to MeHg in fetuses and adults, with a special emphasis on its aberrant effects in the developing central nervous system. Discussions on risk assessment, treatment, and future directions are also covered in this chapter.

Original language	English (US)
Title of host publication	Reproductive and Developmental Toxicology
Publisher	Elsevier
Pages	573-585
Number of pages	13
ISBN (Electronic)	9780323897730
ISBN (Print)	9780323915601
DOIs	https://doi.org/10.1016/B978-0-323-89773-0.00030-8
State	Published - Jan 1 2022

Keywords

Mercury
Methylmercury
Minamata disease
Oxidative stress
Toxicity

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-89773-0.00030-8

Cite this

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title = "Mercury",

abstract = "Methylmercury (MeHg), an organomercurial, is one of the most prevalent and toxic environmental pollutants. The major route of human exposure occurs via consumption of MeHg-adulterated seafood. Historically, MeHg epidemics in Minamata Bay, Japan, and in Iraq provided evidence of its developmental toxicity and neurological damage. This chapter describes MeHg kinetics in the human body and focuses predominantly on mechanisms involved in neuropathological and reproductive effects. The chapter also discusses the differential susceptibility to MeHg in fetuses and adults, with a special emphasis on its aberrant effects in the developing central nervous system. Discussions on risk assessment, treatment, and future directions are also covered in this chapter.",

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AU - Ni, Mingwei

AU - Li, Xin

AU - Santos, Ana Paula Marreilha dos

AU - Farina, Marcelo

AU - Rocha, João Batista Teixeira da

AU - Avila, Daiana S.

AU - Soldin, Offie P.

AU - Rongzhu, Lu

AU - Milatovic, Dejan

AU - Aschner, Michael

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Methylmercury (MeHg), an organomercurial, is one of the most prevalent and toxic environmental pollutants. The major route of human exposure occurs via consumption of MeHg-adulterated seafood. Historically, MeHg epidemics in Minamata Bay, Japan, and in Iraq provided evidence of its developmental toxicity and neurological damage. This chapter describes MeHg kinetics in the human body and focuses predominantly on mechanisms involved in neuropathological and reproductive effects. The chapter also discusses the differential susceptibility to MeHg in fetuses and adults, with a special emphasis on its aberrant effects in the developing central nervous system. Discussions on risk assessment, treatment, and future directions are also covered in this chapter.

AB - Methylmercury (MeHg), an organomercurial, is one of the most prevalent and toxic environmental pollutants. The major route of human exposure occurs via consumption of MeHg-adulterated seafood. Historically, MeHg epidemics in Minamata Bay, Japan, and in Iraq provided evidence of its developmental toxicity and neurological damage. This chapter describes MeHg kinetics in the human body and focuses predominantly on mechanisms involved in neuropathological and reproductive effects. The chapter also discusses the differential susceptibility to MeHg in fetuses and adults, with a special emphasis on its aberrant effects in the developing central nervous system. Discussions on risk assessment, treatment, and future directions are also covered in this chapter.

KW - Mercury

KW - Methylmercury

KW - Minamata disease

KW - Oxidative stress

KW - Toxicity

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SN - 9780323915601

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EP - 585

BT - Reproductive and Developmental Toxicology

PB - Elsevier

ER -

Mercury

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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