Memory Binding Test Predicts Incident Dementia: Results from the Einstein Aging Study

Wenzhu Bi Mowrey, Richard B. Lipton, Mindy Joy Katz, Wendy S. Ramratan, David A. Loewenstein, Molly E. Zimmerman, Herman Buschke

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: The Memory Binding Test (MBT) demonstrated good cross-sectional discriminative validity and predicted incident aMCI. Objective: To assess whether the MBT predicts incident dementia better than a conventional list learning test in a longitudinal community-based study. Methods: As a sub-study in the Einstein Aging Study, 309 participants age ≥ 70 initially free of dementia were administered the MBT and followed annually for incident dementia for up to 13 years. Based on previous work, poor memory binding was defined using an optimal empirical cut-score of ≥17 on the binding measure of the MBT, Total Items in the Paired condition (TIP). Cox proportional hazards models were used to assess predictive validity adjusting for covariates. We compared the predictive validity ofMBTTIP to that of thefree and cued selectivereminding testfreerecall score(FCSRT-FR; cut-score:≤24) and the single list recall measure of the MBT, Cued Recalled from List 1 (CR-L1; cut-score:≤12). Results: Thirty-five of 309 participants developed incident dementia. When assessing each test alone, the hazard ratio (HR) for dementia was significant for MBT TIP (HR = 8.58, 95% CI: (3.58, 20.58), p < 0.0001), FCSRT-FR (HR = 4.19, 95% CI: (1.94, 9.04), p = 0.0003) and MBT CR-L1 (HR = 2.91, 95% CI: (1.37, 6.18), p = 0.006). MBT TIP remained a significant predictor of dementia (p = 0.0002) when adjusting for FCSRT-FR or CR-L1. Conclusions: Older adults with poor memory binding as measured by the MBT TIP were at increased risk for incident dementia. This measure outperforms conventional episodic memory measures of free and cued recall, supporting the memory binding hypothesis.

Original languageEnglish (US)
Pages (from-to)293-304
Number of pages12
JournalJournal of Alzheimer's Disease
Volume62
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Aging
  • Alzheimer's disease
  • cognition
  • dementia
  • longitudinal studies
  • memory
  • survival analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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