Membrane transport of methotrexate (NSC 740) and other folate compounds: relevance to rescue protocols

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

This paper reviews the properties of the membrane transport of methotrexate (MTX) and the tetrahydrofolate cofactors; considers the factors that control the level of free intracellular MTX; and analyzes the possible consequences of the interaction between these substances at the level of the cell membrane that may influence the effectiveness of 'rescue' protocols. This approach may facilitate the design of more effective treatment regimens employing high doses of MTX with folinic acid 'rescue'.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalCANCER CHEMOTHER.REP.
Volume6
Issue number1
StatePublished - Jan 1 1975
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this