Membrane specializations of dendritic spines and glia in the weaver mouse cerebellum

a freeze fracture study

R. B. Hanna, A. Hirano, G. D. Pappas

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Electron microscopy of thin sectioned and freeze fractured preparations of the cerebellum of the weaver mouse indicates that the dendritic spines are morphologically identical to those of their normal littermates. The weaver dendritic spines have been characterized as 'unattached' since the synaptic input from the parallel fibers is absent (8 to 10). The entire region around the dendritic spines is taken up by astrocytic processes in the weaver. The outer fracture face of a normal dendritic spine contains aggregations of 10 nm wide particles in the immediate postsynaptic region. Similar particle aggregations occur in the unattached spines of the weaver. Freeze fracture preparations reveal rectilinear arrays of particles, having a 7 nm center to center distance in the glial membranes. Rectilinear arrays are apparently distributed throughout the astrocyte membrane.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalJournal of Cell Biology
Volume68
Issue number3
StatePublished - 1976

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Neurologic Mutant Mice
Dendritic Spines
Neuroglia
Cerebellum
Membranes
Astrocytes
Electron Microscopy
Spine

ASJC Scopus subject areas

  • Cell Biology

Cite this

Membrane specializations of dendritic spines and glia in the weaver mouse cerebellum : a freeze fracture study. / Hanna, R. B.; Hirano, A.; Pappas, G. D.

In: Journal of Cell Biology, Vol. 68, No. 3, 1976, p. 403-410.

Research output: Contribution to journalArticle

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