Membrane specializations of dentritic spines and glia in the weaver mouse cerebellum: A freeze-fracture study

Robert B. Hanna, Asao Hirano, George D. Pappas

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Electron microscopy of thin-sectioned and freeze-fractured preparations of the cerebellum of the weaver mouse indicates that the dendritic spines are morphologically identical to those of their normal littermates. The weaver dendritic spines have been characterized as "unattached" since the synaptic input from the parallel fibers is absent (8-10). The entire region around the dendritic spines is taken up by astrocytic processes in the weaver. The outer fracture face of a normal dendritic spine contains aggregations of 10-nm wide particles in the immediate postsynaptic region. Similar particle aggregations occur in the unattached spines of the weaver. Freeze-fracture preparations reveal rectilinear arrays of particles, having a 7-nm center-to-center distance in the glial membranes. Rectilinear arrays are apparently distributed throughout the astrocyte membrane.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalJournal of Cell Biology
Volume68
Issue number3
DOIs
StatePublished - Mar 1 1976

ASJC Scopus subject areas

  • Cell Biology

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