Melanocytes in development and cancer

Audrey M. Uong, Leonard I. Zon

Research output: Contribution to journalShort survey

74 Citations (Scopus)

Abstract

Melanocytes are pigment-producing cells in the skin of humans and other vertebrates. A number of genes involved in melanocyte development and vertebrate pigmentation have been characterized, largely through studies of a diversity of pigment mutations in a variety of species. Embryonic development of the melanocyte initiates with cell fate specification in the neural crest, which is then followed by cell migration and niche localization. Many genes involved in melanocyte development have also been implicated in the development of melanoma, an aggressive and fatal form of skin cancer that originates in the melanocyte. Although early stage melanomas that have not spread to the lymph nodes can be excised with little risk of recurrence, patients diagnosed with metastatic melanoma have a high mortality rate due to the resistance of most tumors to radiotherapy and chemotherapy. Transformed melanocytes that develop into melanomas proliferate abnormally and often begin to grow radially in the skin. Vertical growth can then follow this radial growth, leading to an invasion through the basement membrane into the underlying dermis and subsequent metastasis. It is still unclear, however, how a normal melanocyte becomes a melanoma cell, and how melanoma utilizes the properties of the normal melanocyte and its progenitors in its progression. The goal of this mini-review is to highlight the role of melanocyte developmental pathways in melanoma, and to discuss recent studies and tools being used to illuminate this connection.

Original languageEnglish (US)
Pages (from-to)38-41
Number of pages4
JournalJournal of Cellular Physiology
Volume222
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Fingerprint

Melanocytes
Skin
Melanoma
Pigments
Genes
Neoplasms
Chemotherapy
Radiotherapy
Tumors
Specifications
Vertebrates
Neural Crest
Pigmentation
Skin Neoplasms
Dermis
Growth
Basement Membrane
Embryonic Development
Cell Movement
Lymph Nodes

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

Melanocytes in development and cancer. / Uong, Audrey M.; Zon, Leonard I.

In: Journal of Cellular Physiology, Vol. 222, No. 1, 01.2010, p. 38-41.

Research output: Contribution to journalShort survey

Uong, Audrey M. ; Zon, Leonard I. / Melanocytes in development and cancer. In: Journal of Cellular Physiology. 2010 ; Vol. 222, No. 1. pp. 38-41.
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