Medullary control of lumbar motoneurons during carbachol-induced motor inhibition

Alberto E. Pereda, Francisco R. Morales, Michael H. Chase

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The present study examined the effects of stimulation of the medullary nucleus reticularis gigantocellularis (NRGc) on the Ia-monosynaptic reflex and the membrane potential of lumbar motoneurons. Stimulation of the NRGc was carried out in acute decerebrate cats during motor suppression induced by the intrapontine microinjection of carbachol. During carbachol-induced motor suppression, compared with control conditions (prior to the administration of carbachol), NRGc stimulation resulted in a statistically significant reduction in the Ia-monosynaptic reflex. This effect was maximal at an interval of 45 ms following NRGc stimulation. NRGc stimulation also induced, in lumbar motoneurons, a large amplitude (3.17 mV ± 0.36 [S.E.M.]), long duration (54.73 ms ± 3.52 [S.E.M.]) inhibitory postsynaptic potential whose peak coincided with the interval of maximum reflex suppression. These results suggest that carbachol activates pontine neurons that excite cells of the medullary NRGc. We believe that these medullary neurons, in addition to those of the nucleus pontis oralis (NPO)7, participate in the modulation of the descending inhibitory pathway that is responsible for the phenomenon of response-reversal5,15 and generalized atonia during naturally occurring active (i.e. REM) sleep.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalBrain Research
Volume514
Issue number1
DOIs
StatePublished - Apr 23 1990
Externally publishedYes

Keywords

  • Active sleep
  • Carbachol
  • Inhibitory postsynaptic potential
  • Motor suppression
  • Reticular formation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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