Medical complications of cocaine

Changes in pattern of use and spectrum of complications

Rhonda B. Rubin, Joel Neugarten

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We sought to determine whether changes in patterns of cocaine use, characterized by widespread abuse of cocaine alkaloid, have altered the nature and severity of medical complications over the past decade. Infectious complications, almost invariably associated with intravenous use, accounted for nearly all hospital admissions in the early 1980s. Cardiovascular, neurologic and psychiatric complications rose dramatically after 1987 both in absolute number and as a proportion of total complications. This rise parallelled increases in the absolute number and proportion of hospitalized patients smoking cocaine alkaloid or using intranasal cocaine, both disproportionately associated with non-infectious complications. While infectious complications were often local in nature, serious neurologic and cardiovascular sequelae were observed. These data indicate that changes in patterns of cocaine use have altered the nature and increased the severity of medical complications with a shift from infectious to cardiovascular, neurologic and psychiatric complications which may be life-threatening and associated with substantial morbidity.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalClinical Toxicology
Volume30
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Cocaine
Nervous System
Alkaloids
Psychiatry
Cocaine-Related Disorders
Smoking
Morbidity

Keywords

  • Cocaine
  • Cocaine alkaloid
  • Crack-cocaine

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Medical complications of cocaine : Changes in pattern of use and spectrum of complications. / Rubin, Rhonda B.; Neugarten, Joel.

In: Clinical Toxicology, Vol. 30, No. 1, 1992, p. 1-12.

Research output: Contribution to journalArticle

@article{e9f750307b114e26956bcb02da2b520b,
title = "Medical complications of cocaine: Changes in pattern of use and spectrum of complications",
abstract = "We sought to determine whether changes in patterns of cocaine use, characterized by widespread abuse of cocaine alkaloid, have altered the nature and severity of medical complications over the past decade. Infectious complications, almost invariably associated with intravenous use, accounted for nearly all hospital admissions in the early 1980s. Cardiovascular, neurologic and psychiatric complications rose dramatically after 1987 both in absolute number and as a proportion of total complications. This rise parallelled increases in the absolute number and proportion of hospitalized patients smoking cocaine alkaloid or using intranasal cocaine, both disproportionately associated with non-infectious complications. While infectious complications were often local in nature, serious neurologic and cardiovascular sequelae were observed. These data indicate that changes in patterns of cocaine use have altered the nature and increased the severity of medical complications with a shift from infectious to cardiovascular, neurologic and psychiatric complications which may be life-threatening and associated with substantial morbidity.",
keywords = "Cocaine, Cocaine alkaloid, Crack-cocaine",
author = "Rubin, {Rhonda B.} and Joel Neugarten",
year = "1992",
doi = "10.3109/15563659208994441",
language = "English (US)",
volume = "30",
pages = "1--12",
journal = "Clinical Toxicology",
issn = "1556-3650",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Medical complications of cocaine

T2 - Changes in pattern of use and spectrum of complications

AU - Rubin, Rhonda B.

AU - Neugarten, Joel

PY - 1992

Y1 - 1992

N2 - We sought to determine whether changes in patterns of cocaine use, characterized by widespread abuse of cocaine alkaloid, have altered the nature and severity of medical complications over the past decade. Infectious complications, almost invariably associated with intravenous use, accounted for nearly all hospital admissions in the early 1980s. Cardiovascular, neurologic and psychiatric complications rose dramatically after 1987 both in absolute number and as a proportion of total complications. This rise parallelled increases in the absolute number and proportion of hospitalized patients smoking cocaine alkaloid or using intranasal cocaine, both disproportionately associated with non-infectious complications. While infectious complications were often local in nature, serious neurologic and cardiovascular sequelae were observed. These data indicate that changes in patterns of cocaine use have altered the nature and increased the severity of medical complications with a shift from infectious to cardiovascular, neurologic and psychiatric complications which may be life-threatening and associated with substantial morbidity.

AB - We sought to determine whether changes in patterns of cocaine use, characterized by widespread abuse of cocaine alkaloid, have altered the nature and severity of medical complications over the past decade. Infectious complications, almost invariably associated with intravenous use, accounted for nearly all hospital admissions in the early 1980s. Cardiovascular, neurologic and psychiatric complications rose dramatically after 1987 both in absolute number and as a proportion of total complications. This rise parallelled increases in the absolute number and proportion of hospitalized patients smoking cocaine alkaloid or using intranasal cocaine, both disproportionately associated with non-infectious complications. While infectious complications were often local in nature, serious neurologic and cardiovascular sequelae were observed. These data indicate that changes in patterns of cocaine use have altered the nature and increased the severity of medical complications with a shift from infectious to cardiovascular, neurologic and psychiatric complications which may be life-threatening and associated with substantial morbidity.

KW - Cocaine

KW - Cocaine alkaloid

KW - Crack-cocaine

UR - http://www.scopus.com/inward/record.url?scp=0026606882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026606882&partnerID=8YFLogxK

U2 - 10.3109/15563659208994441

DO - 10.3109/15563659208994441

M3 - Article

VL - 30

SP - 1

EP - 12

JO - Clinical Toxicology

JF - Clinical Toxicology

SN - 1556-3650

IS - 1

ER -