Mediators of the inflammatory response to joint replacement devices

Neil Cobelli, Brian Scharf, Giovanna M. Crisi, John Hardin, Laura Santambrogio

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Joint replacement surgery is one of the success stories of modern medicine, restoring mobility, diminishing pain and improving the overall quality of life for millions of people. Unfortunately, wear of these prostheses over time generates debris, which activates an innate immune response that can ultimately lead to periprosthetic resorption of bone (osteolysis) and failure of the implant. Over the past decade, the biological interactions between the particulate debris from various implant materials and the immune system have begun to be better understood. The wear debris induces a multifaceted immune response encompassing the generation of reactive oxygen species and damage-associated molecular patterns, Toll-like receptor signaling and NALP3 inflammasome activation. Acting alone or in concert, these events generate chronic inflammation, periprosthetic bone loss and decreased osteointegration that ultimately leads to implant failure.

Original languageEnglish (US)
Pages (from-to)600-608
Number of pages9
JournalNature Reviews Rheumatology
Volume7
Issue number10
DOIs
StatePublished - Oct 2011

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Replacement Arthroplasties
Inflammasomes
Osteitis
Modern 1601-history
Osteolysis
Toll-Like Receptors
Bone Resorption
Innate Immunity
Prostheses and Implants
Immune System
Reactive Oxygen Species
Quality of Life
Pain
Equipment and Supplies

ASJC Scopus subject areas

  • Rheumatology

Cite this

Mediators of the inflammatory response to joint replacement devices. / Cobelli, Neil; Scharf, Brian; Crisi, Giovanna M.; Hardin, John; Santambrogio, Laura.

In: Nature Reviews Rheumatology, Vol. 7, No. 10, 10.2011, p. 600-608.

Research output: Contribution to journalArticle

Cobelli, Neil ; Scharf, Brian ; Crisi, Giovanna M. ; Hardin, John ; Santambrogio, Laura. / Mediators of the inflammatory response to joint replacement devices. In: Nature Reviews Rheumatology. 2011 ; Vol. 7, No. 10. pp. 600-608.
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