Mediators of the association between age of first sexual intercourse and subsequent human papillomavirus infection.

Jessica A. Kahn, Susan L. Rosenthal, Paul A. Succop, Gloria Y F Ho, Robert D. Burk

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

OBJECTIVE: Previous studies have demonstrated that early age of first sexual intercourse is associated with human papillomavirus (HPV) infection. The objective of this study was to identify a set of risk behaviors and partner characteristics that mediate the association between age of first sexual intercourse and subsequent HPV infection in adolescent and young adult women. METHODS: Female university students completed surveys and underwent HPV testing every 6 months for up to 3 years. HPV-positive participants were matched to HPV-negative participants (252 pairs, total N = 504). Associations were examined between risk behaviors/partner characteristics and both age of first sexual intercourse and HPV infection. Those variables associated with either age of first sexual intercourse or HPV infection were entered into a generalized estimating equation (to account for the matched study design) modeling the association between age of first sexual intercourse and HPV infection. RESULTS: Mean age of first sexual intercourse was 16.7 (+/-1.8) years, and early age of first sexual intercourse was associated significantly with HPV infection (beta = -0.20; odds ratio: 0.82; 95% confidence interval: 0.74-0.90). The association was mediated by number of sexual partners in the past 6 months, history of sexually transmitted infection, alcohol and drug use related to sexual behaviors, and partner's number of sexual partners. CONCLUSION: A set of behavioral risk factors and partner characteristics partially mediate the association between age of first sexual intercourse and subsequent HPV infection.

Original languageEnglish (US)
JournalPediatrics
Volume109
Issue number1
StatePublished - Jan 2002
Externally publishedYes

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Papillomavirus Infections
Coitus
Sexual Partners
Risk-Taking
Sexually Transmitted Diseases
Sexual Behavior

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mediators of the association between age of first sexual intercourse and subsequent human papillomavirus infection. / Kahn, Jessica A.; Rosenthal, Susan L.; Succop, Paul A.; Ho, Gloria Y F; Burk, Robert D.

In: Pediatrics, Vol. 109, No. 1, 01.2002.

Research output: Contribution to journalArticle

Kahn, Jessica A. ; Rosenthal, Susan L. ; Succop, Paul A. ; Ho, Gloria Y F ; Burk, Robert D. / Mediators of the association between age of first sexual intercourse and subsequent human papillomavirus infection. In: Pediatrics. 2002 ; Vol. 109, No. 1.
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