Mechanisms of Trypanosoma cruzi persistence in Chagas disease

Fnu Nagajyothi, Fabiana S. Machado, Barbara A. Burleigh, Linda A. Jelicks, Philipp E. Scherer, Shankar Mukherjee, Michael P. Lisanti, Louis M. Weiss, Nisha J. Garg, Herbert B. Tanowitz

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Trypanosoma cruzi infection leads to development of chronic Chagas disease. In this article, we provide an update on the current knowledge of the mechanisms employed by the parasite to gain entry into the host cells and establish persistent infection despite activation of a potent immune response by the host. Recent studies point to a number of T.cruzi molecules that interact with host cell receptors to promote parasite invasion of the diverse host cells. T.cruzi expresses an antioxidant system and thromboxane A 2 to evade phagosomal oxidative assault and suppress the host's ability to clear parasites. Additional studies suggest that besides cardiac and smooth muscle cells that are the major target of T.cruzi infection, adipocytes and adipose tissue serve as reservoirs from where T.cruzi can recrudesce and cause disease decades later. Further, T.cruzi employs at least four strategies to maintain a symbiotic-like relationship with the host, and ensure consistent supply of nutrients for its own survival and long-term persistence. Ongoing and future research will continue to help refining the models of T.cruzi invasion and persistence in diverse tissues and organs in the host.

Original languageEnglish (US)
Pages (from-to)634-643
Number of pages10
JournalCellular Microbiology
Volume14
Issue number5
DOIs
StatePublished - May 2012

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Chagas Disease
Trypanosoma cruzi
Parasites
Infection
Thromboxanes
varespladib methyl
Adipocytes
Cardiac Myocytes
Smooth Muscle Myocytes
Adipose Tissue
Chronic Disease
Antioxidants
Food

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

Cite this

Nagajyothi, F., Machado, F. S., Burleigh, B. A., Jelicks, L. A., Scherer, P. E., Mukherjee, S., ... Tanowitz, H. B. (2012). Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Cellular Microbiology, 14(5), 634-643. https://doi.org/10.1111/j.1462-5822.2012.01764.x

Mechanisms of Trypanosoma cruzi persistence in Chagas disease. / Nagajyothi, Fnu; Machado, Fabiana S.; Burleigh, Barbara A.; Jelicks, Linda A.; Scherer, Philipp E.; Mukherjee, Shankar; Lisanti, Michael P.; Weiss, Louis M.; Garg, Nisha J.; Tanowitz, Herbert B.

In: Cellular Microbiology, Vol. 14, No. 5, 05.2012, p. 634-643.

Research output: Contribution to journalArticle

Nagajyothi, F, Machado, FS, Burleigh, BA, Jelicks, LA, Scherer, PE, Mukherjee, S, Lisanti, MP, Weiss, LM, Garg, NJ & Tanowitz, HB 2012, 'Mechanisms of Trypanosoma cruzi persistence in Chagas disease', Cellular Microbiology, vol. 14, no. 5, pp. 634-643. https://doi.org/10.1111/j.1462-5822.2012.01764.x
Nagajyothi F, Machado FS, Burleigh BA, Jelicks LA, Scherer PE, Mukherjee S et al. Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Cellular Microbiology. 2012 May;14(5):634-643. https://doi.org/10.1111/j.1462-5822.2012.01764.x
Nagajyothi, Fnu ; Machado, Fabiana S. ; Burleigh, Barbara A. ; Jelicks, Linda A. ; Scherer, Philipp E. ; Mukherjee, Shankar ; Lisanti, Michael P. ; Weiss, Louis M. ; Garg, Nisha J. ; Tanowitz, Herbert B. / Mechanisms of Trypanosoma cruzi persistence in Chagas disease. In: Cellular Microbiology. 2012 ; Vol. 14, No. 5. pp. 634-643.
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