Mechanisms of mitral annular calcification

Daniele Massera, Jorge Kizer, Marc R. Dweck

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The mitral annulus is a fibrous structure that surrounds the mitral valve leaflets and is prone to calcification. Despite its common occurrence, association with cardiovascular morbidity and mortality and relationship with dysfunction of the mitral valve, the pathobiology of mitral annular calcification is incompletely understood. Mitral annular calcification is no longer regarded as a local, chronic and degenerative process resulting in precipitation of calcium and phosphate, but as an active and regulated molecular process that is related to lipid metabolism, hemodynamic stress, chronic kidney disease, bone and mineral metabolism and inflammation. This review summarizes the current evidence examining the pathophysiologic determinants of mitral annular calcification.

Original languageEnglish (US)
JournalTrends in Cardiovascular Medicine
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Mitral Valve
Chronic Renal Insufficiency
Lipid Metabolism
Minerals
Hemodynamics
Inflammation
Morbidity
Bone and Bones
Mortality
calcium phosphate

Keywords

  • Aging
  • Mitral annular calcification
  • Valve disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Mechanisms of mitral annular calcification. / Massera, Daniele; Kizer, Jorge; Dweck, Marc R.

In: Trends in Cardiovascular Medicine, 01.01.2019.

Research output: Contribution to journalReview article

Massera, Daniele ; Kizer, Jorge ; Dweck, Marc R. / Mechanisms of mitral annular calcification. In: Trends in Cardiovascular Medicine. 2019.
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