Mechanism of ribosome assisted protein folding: A new insight into rRNA functions

Dibyendu Samanta, Anindita Das, Arpita Bhattacharya, Arunima Basu, Debasis Das, Chanchal DasGupta

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations

Abstract

The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume384
Issue number2
DOIs
StatePublished - Jun 26 2009

Keywords

  • Domain V of 23S rRNA
  • Protein folding by ribosome
  • Ribosomal exit tunnel

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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