Mechanism of ribosome assisted protein folding: A new insight into rRNA functions

Dibyendu Samanta, Anindita Das, Arpita Bhattacharya, Arunima Basu, Debasis Das, Chanchal DasGupta

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume384
Issue number2
DOIs
StatePublished - Jun 26 2009
Externally publishedYes

Fingerprint

Protein folding
Protein Folding
Ribosomes
Peptidyl Transferases
Protein Unfolding
Nucleic Acids
Modulators
Bacteria
Polymers
Nucleotides
Crystal structure
RNA
Amino Acids
DNA
Proteins

Keywords

  • Domain V of 23S rRNA
  • Protein folding by ribosome
  • Ribosomal exit tunnel

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Mechanism of ribosome assisted protein folding : A new insight into rRNA functions. / Samanta, Dibyendu; Das, Anindita; Bhattacharya, Arpita; Basu, Arunima; Das, Debasis; DasGupta, Chanchal.

In: Biochemical and Biophysical Research Communications, Vol. 384, No. 2, 26.06.2009, p. 137-140.

Research output: Contribution to journalArticle

Samanta, Dibyendu ; Das, Anindita ; Bhattacharya, Arpita ; Basu, Arunima ; Das, Debasis ; DasGupta, Chanchal. / Mechanism of ribosome assisted protein folding : A new insight into rRNA functions. In: Biochemical and Biophysical Research Communications. 2009 ; Vol. 384, No. 2. pp. 137-140.
@article{bb267da68f5340b28b4b3775f7b64403,
title = "Mechanism of ribosome assisted protein folding: A new insight into rRNA functions",
abstract = "The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.",
keywords = "Domain V of 23S rRNA, Protein folding by ribosome, Ribosomal exit tunnel",
author = "Dibyendu Samanta and Anindita Das and Arpita Bhattacharya and Arunima Basu and Debasis Das and Chanchal DasGupta",
year = "2009",
month = "6",
day = "26",
doi = "10.1016/j.bbrc.2009.04.106",
language = "English (US)",
volume = "384",
pages = "137--140",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Mechanism of ribosome assisted protein folding

T2 - A new insight into rRNA functions

AU - Samanta, Dibyendu

AU - Das, Anindita

AU - Bhattacharya, Arpita

AU - Basu, Arunima

AU - Das, Debasis

AU - DasGupta, Chanchal

PY - 2009/6/26

Y1 - 2009/6/26

N2 - The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.

AB - The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.

KW - Domain V of 23S rRNA

KW - Protein folding by ribosome

KW - Ribosomal exit tunnel

UR - http://www.scopus.com/inward/record.url?scp=65549124189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549124189&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2009.04.106

DO - 10.1016/j.bbrc.2009.04.106

M3 - Article

C2 - 19401192

AN - SCOPUS:65549124189

VL - 384

SP - 137

EP - 140

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -