Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest

Nilsson Holguin, Jesse Muir, Harlan J. Evans, Yi Xian Qin, Clinton Rubin, Mark E. Wagshul, Stefan Judex

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Loss of functional weight bearing, such as experienced during space flight or bedrest, causes detrimental morphological volume changes to the intervertebral disc (IVD) beyond the normal diurnal cycle (10-13%), and muscle. Bed rest (BR) was used to test the hypothesis that, short-duration, low-magnitude, high-frequency mechanical vibrations will attenuate the IVD swelling and intrinsic back muscle atrophy induced by long-term bedrest. Control and experimental subjects underwent BR for up to 90d and were scanned by CT at 0d and 90d, and by MRI at 0d, 60d, 90d and 8d after completion of BR. In addition, experimental subjects received vibrations at 0.3g and 30Hz for 10min/day. Muscle volume was measured by CT scans and IVD volume was measured by MRI scans. During BR, mechanical vibrations abated the IVD swelling at 60d by 150% and 90d by 65%. Eight days after bed rest, the control group showed a plasticity of 9%, while the experimental group showed no residual change (p>0.05). Mechanical vibrations reduced the intrinsic back muscle atrophy from long-term bed rest by 33% (p>0.05). These data demonstrate the rapid deterioration of the musculoskeletal system with BR but present vibrations as a promising nonpharmacologic countermeasure to disc degeneration and muscle atrophy.

Original languageEnglish (US)
Title of host publicationBioengineering, Proceedings of the Northeast Conference
Pages25-26
Number of pages2
DOIs
StatePublished - 2007
Externally publishedYes
Event33rd Annual Northeast Bioengineering Conference, NEBC - Stony Brook, NY, United States
Duration: Mar 10 2007Mar 11 2007

Other

Other33rd Annual Northeast Bioengineering Conference, NEBC
CountryUnited States
CityStony Brook, NY
Period3/10/073/11/07

Fingerprint

Swelling
Muscle
Bearings (structural)
Musculoskeletal system
Computerized tomography
Space flight
Magnetic resonance imaging
Plasticity
Deterioration

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Holguin, N., Muir, J., Evans, H. J., Qin, Y. X., Rubin, C., Wagshul, M. E., & Judex, S. (2007). Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest. In Bioengineering, Proceedings of the Northeast Conference (pp. 25-26). [4413262] https://doi.org/10.1109/NEBC.2007.4413262

Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest. / Holguin, Nilsson; Muir, Jesse; Evans, Harlan J.; Qin, Yi Xian; Rubin, Clinton; Wagshul, Mark E.; Judex, Stefan.

Bioengineering, Proceedings of the Northeast Conference. 2007. p. 25-26 4413262.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Holguin, N, Muir, J, Evans, HJ, Qin, YX, Rubin, C, Wagshul, ME & Judex, S 2007, Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest. in Bioengineering, Proceedings of the Northeast Conference., 4413262, pp. 25-26, 33rd Annual Northeast Bioengineering Conference, NEBC, Stony Brook, NY, United States, 3/10/07. https://doi.org/10.1109/NEBC.2007.4413262
Holguin N, Muir J, Evans HJ, Qin YX, Rubin C, Wagshul ME et al. Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest. In Bioengineering, Proceedings of the Northeast Conference. 2007. p. 25-26. 4413262 https://doi.org/10.1109/NEBC.2007.4413262
Holguin, Nilsson ; Muir, Jesse ; Evans, Harlan J. ; Qin, Yi Xian ; Rubin, Clinton ; Wagshul, Mark E. ; Judex, Stefan. / Mechanical vibrations reduce the intervertebral disc swelling and muscle atrophy from bed rest. Bioengineering, Proceedings of the Northeast Conference. 2007. pp. 25-26
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