Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study

Steven M. Kawut, R. Graham Barr, W. Craig Johnson, Harjit Chahal, Harikrishna Tandri, Aditya Jain, Michael R. Bristow, Jorge R. Kizer, Emilia Bagiella, Joao A.C. Lima, David A. Bluemke

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Elevated resistance and reduced compliance of the pulmonary vasculature increase right ventricular (RV) afterload. Local and systemic inflammation and haemostatic abnormalities are prominent in pulmonary vascular diseases. We hypothesized that plasma biomarker levels indicating greater inflammation and coagulability associated with pulmonary vascular disease would be associated with RV structure and function measured by cardiac magnetic resonance imaging (MRI). The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac MRI among participants aged 4584 years without clinical cardiovascular disease. We assessed the associations of RV mass, RV end-diastolic volume (RVEDV), RV stroke volume (RVSV) and RV ejection fraction (RVEF) with plasma measures of inflammation (matrix metalloproteinase (MMP)-3 and -9, intercellular adhesion molecule (ICAM)-1, tumour necrosis factor receptor (TNF-R1), and E-selectin) and thrombosis (plasminogen activator inhibitor (PAI)-1, tissue factor, tissue factor pathway inhibitor and CD40 ligand).The study sample included 731 subjects. Higher MMP-9 levels were associated with lower RV mass before and after adjustment for left ventricular (LV) mass (p0.008 and p0.044, respectively). Higher levels of MMP-9 and PAI-1 were also associated with smaller RVEDV (p<0.05). Higher PAI-1 levels were associated with lower RVEF even after adjustment for LV ejection fraction (p0.017). In conclusion, MMP-9 and PAI-1 are associated with changes in RV structure and function which could be potentially related to a subclinical increase in pulmonary vascular resistance.

Original languageEnglish (US)
Pages (from-to)731-738
Number of pages8
JournalBiomarkers
Volume15
Issue number8
DOIs
StatePublished - Dec 1 2010

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Keywords

  • Hypertension
  • Inflammation
  • Pulmonary
  • Thrombosis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Kawut, S. M., Barr, R. G., Johnson, W. C., Chahal, H., Tandri, H., Jain, A., Bristow, M. R., Kizer, J. R., Bagiella, E., Lima, J. A. C., & Bluemke, D. A. (2010). Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study. Biomarkers, 15(8), 731-738. https://doi.org/10.3109/1354750X.2010.516455