Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke

Robert C. Kaplan, Nicholas L. Smith, Stanley Zucker, Susan R. Heckbert, Kenneth Rice, Bruce M. Psaty

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective: We assessed the association of genetic variation in MMP3 and MMP9 with risk of myocardial infarction and stroke. Methods: A case-control study was conducted among members of Group Health (GH), a large-integrated health care delivery system. Case subjects with incident non-fatal myocardial infarction (n = 854), ischemic stroke (n = 367), and hemorrhagic stroke (n = 66) were identified and validated. A matched control group was selected from among GH members without myocardial infarction or stroke (n = 2696). Haplotype-tagging sets of single-nucleotide polymorphisms (SNPs) in MMP3 and MMP9 were genotyped. Results: MMP3 haplotype 2 was associated with reduced risk of myocardial infarction (adjusted odds ratio (OR) per copy = 0.80, 95% confidence interval 0.66, 0.98) and increased risk of hemorrhagic stroke (OR = 1.69, 95% confidence interval 1.05, 2.75). Results for MMP3 haplotype 2 and ischemic stroke resembled those for myocardial infarction but did not achieve statistical significance (OR = 0.85, 95% confidence interval 0.64, 1.12). No individual SNP identified MMP3 haplotype 2, and none of the individual MMP3 SNPs were associated with myocardial infarction or stroke. MMP9 haplotypes or SNPs were not associated with myocardial infarction or stroke. Conclusions: MMP3 haplotype may predict both cardiac events and stroke.

Original languageEnglish (US)
Pages (from-to)130-137
Number of pages8
JournalAtherosclerosis
Volume201
Issue number1
DOIs
StatePublished - Nov 2008

Fingerprint

Matrix Metalloproteinase 3
Stroke
Myocardial Infarction
Haplotypes
Genes
Single Nucleotide Polymorphism
Odds Ratio
Confidence Intervals
Integrated Delivery of Health Care
Health
Case-Control Studies
Research Design
Control Groups

Keywords

  • Genetics
  • Myocardial infarction
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke. / Kaplan, Robert C.; Smith, Nicholas L.; Zucker, Stanley; Heckbert, Susan R.; Rice, Kenneth; Psaty, Bruce M.

In: Atherosclerosis, Vol. 201, No. 1, 11.2008, p. 130-137.

Research output: Contribution to journalArticle

Kaplan, Robert C. ; Smith, Nicholas L. ; Zucker, Stanley ; Heckbert, Susan R. ; Rice, Kenneth ; Psaty, Bruce M. / Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke. In: Atherosclerosis. 2008 ; Vol. 201, No. 1. pp. 130-137.
@article{71d9d36959a94172b31754152c60b8b9,
title = "Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke",
abstract = "Objective: We assessed the association of genetic variation in MMP3 and MMP9 with risk of myocardial infarction and stroke. Methods: A case-control study was conducted among members of Group Health (GH), a large-integrated health care delivery system. Case subjects with incident non-fatal myocardial infarction (n = 854), ischemic stroke (n = 367), and hemorrhagic stroke (n = 66) were identified and validated. A matched control group was selected from among GH members without myocardial infarction or stroke (n = 2696). Haplotype-tagging sets of single-nucleotide polymorphisms (SNPs) in MMP3 and MMP9 were genotyped. Results: MMP3 haplotype 2 was associated with reduced risk of myocardial infarction (adjusted odds ratio (OR) per copy = 0.80, 95{\%} confidence interval 0.66, 0.98) and increased risk of hemorrhagic stroke (OR = 1.69, 95{\%} confidence interval 1.05, 2.75). Results for MMP3 haplotype 2 and ischemic stroke resembled those for myocardial infarction but did not achieve statistical significance (OR = 0.85, 95{\%} confidence interval 0.64, 1.12). No individual SNP identified MMP3 haplotype 2, and none of the individual MMP3 SNPs were associated with myocardial infarction or stroke. MMP9 haplotypes or SNPs were not associated with myocardial infarction or stroke. Conclusions: MMP3 haplotype may predict both cardiac events and stroke.",
keywords = "Genetics, Myocardial infarction, Stroke",
author = "Kaplan, {Robert C.} and Smith, {Nicholas L.} and Stanley Zucker and Heckbert, {Susan R.} and Kenneth Rice and Psaty, {Bruce M.}",
year = "2008",
month = "11",
doi = "10.1016/j.atherosclerosis.2008.01.003",
language = "English (US)",
volume = "201",
pages = "130--137",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Matrix metalloproteinase-3 (MMP3) and MMP9 genes and risk of myocardial infarction, ischemic stroke, and hemorrhagic stroke

AU - Kaplan, Robert C.

AU - Smith, Nicholas L.

AU - Zucker, Stanley

AU - Heckbert, Susan R.

AU - Rice, Kenneth

AU - Psaty, Bruce M.

PY - 2008/11

Y1 - 2008/11

N2 - Objective: We assessed the association of genetic variation in MMP3 and MMP9 with risk of myocardial infarction and stroke. Methods: A case-control study was conducted among members of Group Health (GH), a large-integrated health care delivery system. Case subjects with incident non-fatal myocardial infarction (n = 854), ischemic stroke (n = 367), and hemorrhagic stroke (n = 66) were identified and validated. A matched control group was selected from among GH members without myocardial infarction or stroke (n = 2696). Haplotype-tagging sets of single-nucleotide polymorphisms (SNPs) in MMP3 and MMP9 were genotyped. Results: MMP3 haplotype 2 was associated with reduced risk of myocardial infarction (adjusted odds ratio (OR) per copy = 0.80, 95% confidence interval 0.66, 0.98) and increased risk of hemorrhagic stroke (OR = 1.69, 95% confidence interval 1.05, 2.75). Results for MMP3 haplotype 2 and ischemic stroke resembled those for myocardial infarction but did not achieve statistical significance (OR = 0.85, 95% confidence interval 0.64, 1.12). No individual SNP identified MMP3 haplotype 2, and none of the individual MMP3 SNPs were associated with myocardial infarction or stroke. MMP9 haplotypes or SNPs were not associated with myocardial infarction or stroke. Conclusions: MMP3 haplotype may predict both cardiac events and stroke.

AB - Objective: We assessed the association of genetic variation in MMP3 and MMP9 with risk of myocardial infarction and stroke. Methods: A case-control study was conducted among members of Group Health (GH), a large-integrated health care delivery system. Case subjects with incident non-fatal myocardial infarction (n = 854), ischemic stroke (n = 367), and hemorrhagic stroke (n = 66) were identified and validated. A matched control group was selected from among GH members without myocardial infarction or stroke (n = 2696). Haplotype-tagging sets of single-nucleotide polymorphisms (SNPs) in MMP3 and MMP9 were genotyped. Results: MMP3 haplotype 2 was associated with reduced risk of myocardial infarction (adjusted odds ratio (OR) per copy = 0.80, 95% confidence interval 0.66, 0.98) and increased risk of hemorrhagic stroke (OR = 1.69, 95% confidence interval 1.05, 2.75). Results for MMP3 haplotype 2 and ischemic stroke resembled those for myocardial infarction but did not achieve statistical significance (OR = 0.85, 95% confidence interval 0.64, 1.12). No individual SNP identified MMP3 haplotype 2, and none of the individual MMP3 SNPs were associated with myocardial infarction or stroke. MMP9 haplotypes or SNPs were not associated with myocardial infarction or stroke. Conclusions: MMP3 haplotype may predict both cardiac events and stroke.

KW - Genetics

KW - Myocardial infarction

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=53849138794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53849138794&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2008.01.003

DO - 10.1016/j.atherosclerosis.2008.01.003

M3 - Article

VL - 201

SP - 130

EP - 137

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -