Maternal exercise decreases maternal deprivation induced anxiety of pups and correlates to increased prefrontal cortex BDNF and VEGF

Nazan Uysal, Ali Riza Sisman, Ayfer Dayi, Ilkay Aksu, Ferihan Cetin, Celal Gencoglu, Aysegul Tas, Erkan Buyuk

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Maternal deprivation (MD) may cause neuropsychiatric disorders such as anxiety disorder by negatively affecting the cognitive functions and behavior in pups. The aim of this study is to investigate whether maternal exercise during pregnancy has beneficial effects on anxiety that increases with MD, and on the levels of VEGF and BDNF which have anxiolytic effects on the prefrontal cortex, the anxiety-related region of the brain. The anxiety level in the deprivation group was greater than the control group and found more in male than female pups. The prefrontal cortex VEGF and BDNF levels were decreased in the deprivation group compared to control group while serum corticosterone levels were increased in the deprivation group. Anxiety and serum corticosterone levels were decreased in maternally exercised female and male pups, while the prefrontal cortex VEGF and BDNF levels were increased, compared to sedentary mother's pups. These results indicate that maternal exercise may attenuate the negative effect of stresses such as maternal deprivation that can be encountered early in life.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalNeuroscience Letters
Volume505
Issue number3
DOIs
StatePublished - Nov 21 2011

Fingerprint

Maternal Deprivation
Brain-Derived Neurotrophic Factor
Prefrontal Cortex
Vascular Endothelial Growth Factor A
Anxiety
Mothers
Exercise
Corticosterone
Control Groups
Anti-Anxiety Agents
Anxiety Disorders
Serum
Cognition
Pregnancy
Brain

Keywords

  • Anxiety
  • BDNF
  • Maternal deprivation
  • Maternal exercise
  • Prefrontal cortex
  • Pups
  • VEGF

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maternal exercise decreases maternal deprivation induced anxiety of pups and correlates to increased prefrontal cortex BDNF and VEGF. / Uysal, Nazan; Sisman, Ali Riza; Dayi, Ayfer; Aksu, Ilkay; Cetin, Ferihan; Gencoglu, Celal; Tas, Aysegul; Buyuk, Erkan.

In: Neuroscience Letters, Vol. 505, No. 3, 21.11.2011, p. 273-278.

Research output: Contribution to journalArticle

Uysal, Nazan ; Sisman, Ali Riza ; Dayi, Ayfer ; Aksu, Ilkay ; Cetin, Ferihan ; Gencoglu, Celal ; Tas, Aysegul ; Buyuk, Erkan. / Maternal exercise decreases maternal deprivation induced anxiety of pups and correlates to increased prefrontal cortex BDNF and VEGF. In: Neuroscience Letters. 2011 ; Vol. 505, No. 3. pp. 273-278.
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