Abstract
Selective depletion on CNS dopamine in neonatal rats, by intracisternal injection of 6-hydroxydopamine on the fifth day of life, is associated with hyperactivity, learning disturbances, and growth retardation. To assess the degree to which pup behavioral deficits result from, or influence, alterations in maternal care, mother-pup interaction was investigated during the first 13 days of pup life in 3 groups of litters: 6-OHDA-treated, sham treated, and normal control. Measures of maternal behaviors included nursing, nest-building, retrieval, and locomotor activity; biological measures of pup maturation included weight, length, and righting time. These indices of mother-pup interaction revealed 4 stable dimensions and significant developmental patterns. 6-OHDA-treated pups were significantly lighter and shorter, and somewhat retarded in righting time. Although pup 6-OHDA treatment did not disrupt the organization or sequence of mothering, treated pups were increasingly distinguished from controls by the promptness with which they were retrieved. The profound and enduring behavioral deficits of dopamine depletion in the newborn period appear to occur in the presence of adequate, and perhaps enhanced, maternal care.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-75 |
| Number of pages | 7 |
| Journal | Physiology and Behavior |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1979 |
| Externally published | Yes |
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Keywords
- 6-Hydroxydopamine
- Brain catecholamines
- Dopamine
- Maternal behavior
- Mother-infant interaction
- Rat pup development
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Philosophy
- Behavioral Neuroscience
Cite this
Maternal care received by rat pups treated with 6-hydroxydopamine. / Piccirillo, Mark; Cohen, Donald J.; Shaywitz, Bennett A.; Alpert, Jonathan E.; Marinelli, David.
In: Physiology and Behavior, Vol. 22, No. 1, 1979, p. 69-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maternal care received by rat pups treated with 6-hydroxydopamine
AU - Piccirillo, Mark
AU - Cohen, Donald J.
AU - Shaywitz, Bennett A.
AU - Alpert, Jonathan E.
AU - Marinelli, David
PY - 1979
Y1 - 1979
N2 - Selective depletion on CNS dopamine in neonatal rats, by intracisternal injection of 6-hydroxydopamine on the fifth day of life, is associated with hyperactivity, learning disturbances, and growth retardation. To assess the degree to which pup behavioral deficits result from, or influence, alterations in maternal care, mother-pup interaction was investigated during the first 13 days of pup life in 3 groups of litters: 6-OHDA-treated, sham treated, and normal control. Measures of maternal behaviors included nursing, nest-building, retrieval, and locomotor activity; biological measures of pup maturation included weight, length, and righting time. These indices of mother-pup interaction revealed 4 stable dimensions and significant developmental patterns. 6-OHDA-treated pups were significantly lighter and shorter, and somewhat retarded in righting time. Although pup 6-OHDA treatment did not disrupt the organization or sequence of mothering, treated pups were increasingly distinguished from controls by the promptness with which they were retrieved. The profound and enduring behavioral deficits of dopamine depletion in the newborn period appear to occur in the presence of adequate, and perhaps enhanced, maternal care.
AB - Selective depletion on CNS dopamine in neonatal rats, by intracisternal injection of 6-hydroxydopamine on the fifth day of life, is associated with hyperactivity, learning disturbances, and growth retardation. To assess the degree to which pup behavioral deficits result from, or influence, alterations in maternal care, mother-pup interaction was investigated during the first 13 days of pup life in 3 groups of litters: 6-OHDA-treated, sham treated, and normal control. Measures of maternal behaviors included nursing, nest-building, retrieval, and locomotor activity; biological measures of pup maturation included weight, length, and righting time. These indices of mother-pup interaction revealed 4 stable dimensions and significant developmental patterns. 6-OHDA-treated pups were significantly lighter and shorter, and somewhat retarded in righting time. Although pup 6-OHDA treatment did not disrupt the organization or sequence of mothering, treated pups were increasingly distinguished from controls by the promptness with which they were retrieved. The profound and enduring behavioral deficits of dopamine depletion in the newborn period appear to occur in the presence of adequate, and perhaps enhanced, maternal care.
KW - 6-Hydroxydopamine
KW - Brain catecholamines
KW - Dopamine
KW - Maternal behavior
KW - Mother-infant interaction
KW - Rat pup development
UR - http://www.scopus.com/inward/record.url?scp=0018395482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018395482&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(79)90406-2
DO - 10.1016/0031-9384(79)90406-2
M3 - Article
C2 - 572074
AN - SCOPUS:0018395482
VL - 22
SP - 69
EP - 75
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 1
ER -