Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy

Mary Casey, Ruth Rosenblatt, Jill Zimmerman, Susan A. Fineberg

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mammary carcinoma diagnosed by large-core stereotactic biopsy (LCSBB) is often followed by definitive surgery. We report on positive (malignant) LCSBB followed by definitive surgery that failed to demonstrate malignancy. Between January 1993 and August 1996, 206 women in our institution underwent LCSBB. Carcinoma was diagnosed in 45 patients (22%) of the 206 (ductal carcinoma in situ (DCIS), n = 12; invasive carcinoma, n = 33). Twenty-nine of the 45 patients subsequently underwent mastectomy, and 8 of 45 underwent lumpectomy. In 34 (92%) of these 37 patients, carcinoma was demonstrated at follow-up surgery, but in 3 patients (8%), mastectomy failed to reveal carcinoma. The characteristics of these three patients are as follows: Patient 1 was a 58- year-old woman with a nonpalpable 6- to 8-mm nodule revealed by a screening mammogram. Three of 8 LCSBBs showed colloid carcinoma, but histologic examination of 50 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Patient 2 was a 64-year-old woman with a nonpalpable 6- to 9-mm nodule revealed by mammogram. Six of 12 LCSBBs showed tubular carcinoma, but histologic examination of 30 paraffin blocks from her mastectomy sample failed to reveal carcinoma. Patient 3 was a 72-year-old woman with a history of DCIS. She had undergone a lumpectomy and radiotherapy, and she had suspicious ipsilateral microcalcifications. Two of 8 LCSBBs showed comedo DCIS, but histologic examination of 26 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Possible explanations for a mastectomy without malignancy after carcinoma was diagnosed by LCSBB include removal of the entire lesion by LCSBB, inflammatory response obliterating remaining tumor, false-positive core biopsy result, patient misidentification, inadequate sampling of the surgical specimen, and failure to remove the tumor. We outline a series of steps for the pathologists to follow when confronted with such a case.

Original languageEnglish (US)
Pages (from-to)1209-1213
Number of pages5
JournalModern Pathology
Volume10
Issue number12
StatePublished - Dec 1997

Fingerprint

Mastectomy
Breast
Carcinoma
Biopsy
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Paraffin
Segmental Mastectomy
Calcinosis
Mucinous Adenocarcinoma
Adenocarcinoma
Radiotherapy
Breast Neoplasms

Keywords

  • Biopsy
  • Breast
  • Carcinoma
  • Core Biopsy
  • Stereotactic

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Casey, M., Rosenblatt, R., Zimmerman, J., & Fineberg, S. A. (1997). Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy. Modern Pathology, 10(12), 1209-1213.

Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy. / Casey, Mary; Rosenblatt, Ruth; Zimmerman, Jill; Fineberg, Susan A.

In: Modern Pathology, Vol. 10, No. 12, 12.1997, p. 1209-1213.

Research output: Contribution to journalArticle

Casey, M, Rosenblatt, R, Zimmerman, J & Fineberg, SA 1997, 'Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy', Modern Pathology, vol. 10, no. 12, pp. 1209-1213.
Casey M, Rosenblatt R, Zimmerman J, Fineberg SA. Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy. Modern Pathology. 1997 Dec;10(12):1209-1213.
Casey, Mary ; Rosenblatt, Ruth ; Zimmerman, Jill ; Fineberg, Susan A. / Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy. In: Modern Pathology. 1997 ; Vol. 10, No. 12. pp. 1209-1213.
@article{766c5362dae343c5903e1c61a21249d1,
title = "Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy",
abstract = "Mammary carcinoma diagnosed by large-core stereotactic biopsy (LCSBB) is often followed by definitive surgery. We report on positive (malignant) LCSBB followed by definitive surgery that failed to demonstrate malignancy. Between January 1993 and August 1996, 206 women in our institution underwent LCSBB. Carcinoma was diagnosed in 45 patients (22{\%}) of the 206 (ductal carcinoma in situ (DCIS), n = 12; invasive carcinoma, n = 33). Twenty-nine of the 45 patients subsequently underwent mastectomy, and 8 of 45 underwent lumpectomy. In 34 (92{\%}) of these 37 patients, carcinoma was demonstrated at follow-up surgery, but in 3 patients (8{\%}), mastectomy failed to reveal carcinoma. The characteristics of these three patients are as follows: Patient 1 was a 58- year-old woman with a nonpalpable 6- to 8-mm nodule revealed by a screening mammogram. Three of 8 LCSBBs showed colloid carcinoma, but histologic examination of 50 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Patient 2 was a 64-year-old woman with a nonpalpable 6- to 9-mm nodule revealed by mammogram. Six of 12 LCSBBs showed tubular carcinoma, but histologic examination of 30 paraffin blocks from her mastectomy sample failed to reveal carcinoma. Patient 3 was a 72-year-old woman with a history of DCIS. She had undergone a lumpectomy and radiotherapy, and she had suspicious ipsilateral microcalcifications. Two of 8 LCSBBs showed comedo DCIS, but histologic examination of 26 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Possible explanations for a mastectomy without malignancy after carcinoma was diagnosed by LCSBB include removal of the entire lesion by LCSBB, inflammatory response obliterating remaining tumor, false-positive core biopsy result, patient misidentification, inadequate sampling of the surgical specimen, and failure to remove the tumor. We outline a series of steps for the pathologists to follow when confronted with such a case.",
keywords = "Biopsy, Breast, Carcinoma, Core Biopsy, Stereotactic",
author = "Mary Casey and Ruth Rosenblatt and Jill Zimmerman and Fineberg, {Susan A.}",
year = "1997",
month = "12",
language = "English (US)",
volume = "10",
pages = "1209--1213",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Mastectomy without malignancy after carcinoma diagnosed by large-core stereotactic breast biopsy

AU - Casey, Mary

AU - Rosenblatt, Ruth

AU - Zimmerman, Jill

AU - Fineberg, Susan A.

PY - 1997/12

Y1 - 1997/12

N2 - Mammary carcinoma diagnosed by large-core stereotactic biopsy (LCSBB) is often followed by definitive surgery. We report on positive (malignant) LCSBB followed by definitive surgery that failed to demonstrate malignancy. Between January 1993 and August 1996, 206 women in our institution underwent LCSBB. Carcinoma was diagnosed in 45 patients (22%) of the 206 (ductal carcinoma in situ (DCIS), n = 12; invasive carcinoma, n = 33). Twenty-nine of the 45 patients subsequently underwent mastectomy, and 8 of 45 underwent lumpectomy. In 34 (92%) of these 37 patients, carcinoma was demonstrated at follow-up surgery, but in 3 patients (8%), mastectomy failed to reveal carcinoma. The characteristics of these three patients are as follows: Patient 1 was a 58- year-old woman with a nonpalpable 6- to 8-mm nodule revealed by a screening mammogram. Three of 8 LCSBBs showed colloid carcinoma, but histologic examination of 50 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Patient 2 was a 64-year-old woman with a nonpalpable 6- to 9-mm nodule revealed by mammogram. Six of 12 LCSBBs showed tubular carcinoma, but histologic examination of 30 paraffin blocks from her mastectomy sample failed to reveal carcinoma. Patient 3 was a 72-year-old woman with a history of DCIS. She had undergone a lumpectomy and radiotherapy, and she had suspicious ipsilateral microcalcifications. Two of 8 LCSBBs showed comedo DCIS, but histologic examination of 26 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Possible explanations for a mastectomy without malignancy after carcinoma was diagnosed by LCSBB include removal of the entire lesion by LCSBB, inflammatory response obliterating remaining tumor, false-positive core biopsy result, patient misidentification, inadequate sampling of the surgical specimen, and failure to remove the tumor. We outline a series of steps for the pathologists to follow when confronted with such a case.

AB - Mammary carcinoma diagnosed by large-core stereotactic biopsy (LCSBB) is often followed by definitive surgery. We report on positive (malignant) LCSBB followed by definitive surgery that failed to demonstrate malignancy. Between January 1993 and August 1996, 206 women in our institution underwent LCSBB. Carcinoma was diagnosed in 45 patients (22%) of the 206 (ductal carcinoma in situ (DCIS), n = 12; invasive carcinoma, n = 33). Twenty-nine of the 45 patients subsequently underwent mastectomy, and 8 of 45 underwent lumpectomy. In 34 (92%) of these 37 patients, carcinoma was demonstrated at follow-up surgery, but in 3 patients (8%), mastectomy failed to reveal carcinoma. The characteristics of these three patients are as follows: Patient 1 was a 58- year-old woman with a nonpalpable 6- to 8-mm nodule revealed by a screening mammogram. Three of 8 LCSBBs showed colloid carcinoma, but histologic examination of 50 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Patient 2 was a 64-year-old woman with a nonpalpable 6- to 9-mm nodule revealed by mammogram. Six of 12 LCSBBs showed tubular carcinoma, but histologic examination of 30 paraffin blocks from her mastectomy sample failed to reveal carcinoma. Patient 3 was a 72-year-old woman with a history of DCIS. She had undergone a lumpectomy and radiotherapy, and she had suspicious ipsilateral microcalcifications. Two of 8 LCSBBs showed comedo DCIS, but histologic examination of 26 paraffin blocks and radiographic examination of the mastectomy sample failed to reveal carcinoma. Possible explanations for a mastectomy without malignancy after carcinoma was diagnosed by LCSBB include removal of the entire lesion by LCSBB, inflammatory response obliterating remaining tumor, false-positive core biopsy result, patient misidentification, inadequate sampling of the surgical specimen, and failure to remove the tumor. We outline a series of steps for the pathologists to follow when confronted with such a case.

KW - Biopsy

KW - Breast

KW - Carcinoma

KW - Core Biopsy

KW - Stereotactic

UR - http://www.scopus.com/inward/record.url?scp=0004579422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0004579422&partnerID=8YFLogxK

M3 - Article

C2 - 9436965

AN - SCOPUS:0004579422

VL - 10

SP - 1209

EP - 1213

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 12

ER -