Markovian model of the voltage gating of connexin-based gap junction channels

A. Sakalauskaite, H. Pranevicius, M. Pranevicius, F. Bukauskas

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Gap junction (GJ) channels, which are formed of a connexin (Cx) protein provide pathways through which ions and small molecules are exchanged between adjacent cells. GJs co-ordinate the cellular activity in tissues by synchronizing their electrical activity and allowing a direct cell-to-cell chemical signaling. Electrically gap junctions present nonlinear conductance that depends on transjunctional voltage and can be modulated by chemical reagents and ions, such as pH, Ca2+, etc. Here, we describe the model of the voltage gating of gap junctions using Markovian formalism. The results obtained using a stationary Markov model are well comparable with those obtained using a stochastic/imitational model of voltage gating.

Original languageEnglish (US)
Pages (from-to)103-106
Number of pages4
JournalElektronika ir Elektrotechnika
Issue number5
StatePublished - May 1 2011

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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    Sakalauskaite, A., Pranevicius, H., Pranevicius, M., & Bukauskas, F. (2011). Markovian model of the voltage gating of connexin-based gap junction channels. Elektronika ir Elektrotechnika, (5), 103-106.