TY - JOUR
T1 - Markers of erectile dysfunction
AU - Davies, Kelvin P.
AU - Melman, Arnold
PY - 2008/7/1
Y1 - 2008/7/1
N2 - With the development and marketing of oral pharmacotherapy that is both noninvasive and successful in treating erectile dysfunction (ED), the quest to identify markers of organic ED lost ground. Indeed, the multi-factorial nature of ED may have led many researchers to conclude that searching for a universal marker of ED was futile. However, the realization that ED is strongly correlated with the overall health of men, and may act as a predictor for the development of cardiovascular disease (CVD) and diabetes, has stimulated interest in identifying genes that can distinguish organic ED. In addition, the potential ability to suggest to the patient that ED is reversible (i.e., psychogenic) with a simple test would be of significance to both the physician and patient, as well as for reimbursement issues for therapy by insurance companies. Such a marker may also act as a non-subjective measure of the degree of ED and the efficacy of treatment. This review discusses the importance of identifying such markers and recent work identifying potential markers in human patients.
AB - With the development and marketing of oral pharmacotherapy that is both noninvasive and successful in treating erectile dysfunction (ED), the quest to identify markers of organic ED lost ground. Indeed, the multi-factorial nature of ED may have led many researchers to conclude that searching for a universal marker of ED was futile. However, the realization that ED is strongly correlated with the overall health of men, and may act as a predictor for the development of cardiovascular disease (CVD) and diabetes, has stimulated interest in identifying genes that can distinguish organic ED. In addition, the potential ability to suggest to the patient that ED is reversible (i.e., psychogenic) with a simple test would be of significance to both the physician and patient, as well as for reimbursement issues for therapy by insurance companies. Such a marker may also act as a non-subjective measure of the degree of ED and the efficacy of treatment. This review discusses the importance of identifying such markers and recent work identifying potential markers in human patients.
KW - Biomarker
KW - Erectile dysfunction
UR - http://www.scopus.com/inward/record.url?scp=50949091754&partnerID=8YFLogxK
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U2 - 10.4103/0970-1591.42612
DO - 10.4103/0970-1591.42612
M3 - Review article
C2 - 19468461
AN - SCOPUS:50949091754
SN - 0970-1591
VL - 24
SP - 320
EP - 328
JO - Indian Journal of Urology
JF - Indian Journal of Urology
IS - 3
ER -