MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake

M. Lee, K. Chen, J. C. Shih, Noboru Hiroi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Low levels of monoamine oxidase-B (MAO-B) activity, such as those observed in smokers, are also associated with behavioral traits such as a heightened responsiveness to novelty. However, the exact mechanism by which low MAO-B activity influences smoking and heightened responsiveness to novelty is still poorly understood. We used MAO-B knockout (KO) mice to test the hypothesis that MAO-B concomitantly affects locomotor responses in a novel inescapable open field and nicotine intake. Male wild-type (WT) and MAO-B KO mice were placed in an inescapable open field and their horizontal locomotor activity was measured for 30 min per day for 5 days. MAO-B KO mice exhibited impaired within-session habituation of locomotor activity, as compared to WT mice. Separate groups of male WT and MAO-B KO mice were individually housed in their home cages with two water bottles. One of the bottles contained tap water and the other contained nicotine (0, 3.125, 6.25, 12.5, 25, 50 or 100μg/ml). The total amount of water and nicotine solution consumed was measured every three days for 16 days. MAO-B KO mice and WT mice consumed equal amounts of nicotine and exhibited comparable concentration-dependent nicotine preference and aversion over a period of 16 days. The data suggest that the absence of MAO-B impairs the ability of mice to habituate in the inescapable environment, but does not alter their nicotine intake.

Original languageEnglish (US)
Pages (from-to)216-227
Number of pages12
JournalGenes, Brain and Behavior
Volume3
Issue number4
DOIs
StatePublished - Aug 2004

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Monoamine Oxidase
Locomotion
Nicotine
Knockout Mice
Water
Aptitude
Smoking

Keywords

  • Knockout
  • Locomotor activity
  • MAO-B
  • Nicotine
  • Open field

ASJC Scopus subject areas

  • Neuroscience(all)
  • Genetics

Cite this

MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake. / Lee, M.; Chen, K.; Shih, J. C.; Hiroi, Noboru.

In: Genes, Brain and Behavior, Vol. 3, No. 4, 08.2004, p. 216-227.

Research output: Contribution to journalArticle

Lee, M. ; Chen, K. ; Shih, J. C. ; Hiroi, Noboru. / MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake. In: Genes, Brain and Behavior. 2004 ; Vol. 3, No. 4. pp. 216-227.
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