Manganese transport in eukaryotes: The role of DMT1

Catherine Au, Alexandre Benedetto, Michael Aschner

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Manganese (Mn) is a transition metal that is essential for normal cell growth and development, but is toxic at high concentrations. While Mn deficiency is uncommon in humans, Mn toxicity is known to be readily prevalent due to occupational overexposure in miners, smelters and possibly welders. Excessive exposure to Mn can cause Parkinson's disease-like syndrome; patients typically exhibit extrapyramidal symptoms that include tremor, rigidity and hypokinesia [Calne DB, Chu NS, Huang CC, Lu CS, Olanow W. Manganism and idiopathic parkinsonism: similarities and differences. Neurology 1994;44(9):1583-6; Dobson AW, Erikson KM, Aschner M. Manganese neurotoxicity. Ann NY Acad Sci 2004;1012:115-28]. Mn-induced motor neuron diseases have been the subjects of numerous studies; however, this review is not intended to discuss its neurotoxic potential or its role in the etiology of motor neuron disorders. Rather, it will focus on Mn uptake and transport via the orthologues of the divalent metal transporter (DMT1) and its possible implications to Mn toxicity in various categories of eukaryotic systems, such as in vitro cell lines, in vivo rodents, the fruitfly, Drosophila melanogaster, the honeybee, Apis mellifera L., the nematode, Caenorhabditis elegans and the baker's yeast, Saccharomyces cerevisiae.

Original languageEnglish (US)
Pages (from-to)569-576
Number of pages8
JournalNeuroToxicology
Volume29
Issue number4
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Manganese
Eukaryota
Yeast
Neurons
Toxicity
Saccharomyces cerevisiae
Metals
Hypokinesia
Motor Neuron Disease
Miners
Poisons
Bees
Caenorhabditis elegans
Parkinsonian Disorders
Cell growth
Neurology
Motor Neurons
Tremor
Drosophila melanogaster
Growth and Development

Keywords

  • DMT1
  • Manganese
  • NRAMP-2
  • Transport

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Manganese transport in eukaryotes : The role of DMT1. / Au, Catherine; Benedetto, Alexandre; Aschner, Michael.

In: NeuroToxicology, Vol. 29, No. 4, 07.2008, p. 569-576.

Research output: Contribution to journalArticle

Au, Catherine ; Benedetto, Alexandre ; Aschner, Michael. / Manganese transport in eukaryotes : The role of DMT1. In: NeuroToxicology. 2008 ; Vol. 29, No. 4. pp. 569-576.
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