Manganese homeostasis and transport

Jerome Roth, Silvia Ponzoni, Michael Aschner

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.

Original languageEnglish (US)
Pages (from-to)169-201
Number of pages33
JournalMetal Ions in Life Sciences
Volume12
DOIs
StatePublished - 2013
Externally publishedYes

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Keywords

  • Divalent metal transporter 1 (DMT1)
  • Manganese
  • Mitochondria
  • Parkin
  • Transport

ASJC Scopus subject areas

  • Medicine(all)

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