Manganese homeostasis and transport

Jerome Roth; Silvia Ponzoni; Michael Aschner

doi:10.1007/978-94-007-5561-1_6

Manganese homeostasis and transport

Jerome Roth, Silvia Ponzoni, Michael Aschner

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.

Original language	English (US)
Pages (from-to)	169-201
Number of pages	33
Journal	Metal Ions in Life Sciences
Volume	12
DOIs	https://doi.org/10.1007/978-94-007-5561-1_6
State	Published - 2013
Externally published	Yes

Keywords

Divalent metal transporter 1 (DMT1)
Manganese
Mitochondria
Parkin
Transport

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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10.1007/978-94-007-5561-1_6

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title = "Manganese homeostasis and transport",

abstract = "The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.",

keywords = "Divalent metal transporter 1 (DMT1), Manganese, Mitochondria, Parkin, Transport",

author = "Jerome Roth and Silvia Ponzoni and Michael Aschner",

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T1 - Manganese homeostasis and transport

AU - Roth, Jerome

AU - Ponzoni, Silvia

AU - Aschner, Michael

PY - 2013

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AB - The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.

KW - Divalent metal transporter 1 (DMT1)

KW - Manganese

KW - Mitochondria

KW - Parkin

KW - Transport

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JO - Metal Ions in Life Sciences

JF - Metal Ions in Life Sciences

ER -

Manganese homeostasis and transport

Abstract

Keywords

ASJC Scopus subject areas

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