Maltoma of the thyroid in a man with Hashimoto's thyroiditis

Robert Wozniak, Lee Beckwith, Howard Ratech, Martin I. Surks

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We report the case of a 42-yr-old man with primary thyroid lymphoma arising from mucosa-associated lymphoid tissue (MALT-lymphoma, maltoma). The patient underwent a hemithyroidectomy for a growing mass in the right lobe of the thyroid while being treated with l-thyroxine for Hashimoto's thyroiditis. The clinical diagnosis of Hashimoto's disease was confirmed by aspiration biopsy of the mass during the course of L-thyroxine treatment. Postoperatively, histology showed atypical lymphoproliferative infiltrates suspicious of low-grade non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue-type, coexisting with a reactive process typical of chronic lymphocytic thyroiditis. Immunophenotyping showed a mixed B- and T-lymphocyte population, which was nondiagnostic. However, Southern blot analysis revealed a clonal rearrangement of the Ig heavy chain gene. This case demonstrates that cytology or histology may not distinguish between reactive or low-grade lymphomatous thyroid processes. The use of molecular technique was essential to prove clonality and the presence of lymphoma.

Original languageEnglish (US)
Pages (from-to)1206-1209
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume84
Issue number4
StatePublished - 1999

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Marginal Zone B-Cell Lymphoma
Hashimoto Disease
Histology
Thyroxine
Thyroid Gland
Cytology
Tissue
Immunoglobulin Heavy Chains
T-cells
Biopsy
Non-Hodgkin's Lymphoma
Genes
Immunophenotyping
Needle Biopsy
Southern Blotting
Cell Biology
Lymphoma
T-Lymphocytes
Mucous Membrane
Population

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Maltoma of the thyroid in a man with Hashimoto's thyroiditis. / Wozniak, Robert; Beckwith, Lee; Ratech, Howard; Surks, Martin I.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 84, No. 4, 1999, p. 1206-1209.

Research output: Contribution to journalArticle

Wozniak, Robert ; Beckwith, Lee ; Ratech, Howard ; Surks, Martin I. / Maltoma of the thyroid in a man with Hashimoto's thyroiditis. In: Journal of Clinical Endocrinology and Metabolism. 1999 ; Vol. 84, No. 4. pp. 1206-1209.
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