Making sense of the multiple MAP-2 transcripts and their role in the neuron

Bridget Shafit-Zagardo, Nellie Kalcheva

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Microtubule-associated protein-2 (MAP-2) is a family of heat-stable, phosphoproteins expressed predominantly in the cell body and dendrites of neurons. Three major MAP-2 isoforms, (MAP-2a, MAP-2b, MAP-2c) are differentially expressed during the development of the nervous system and have an important role in microtubule dynamics. Several MAP-2 cDNA clones that correspond to the major MAP-2 transcripts and additional, novel MAP-2 transcripts expressed in the CNS and PNS have been characterized. The transcripts result from the alternative splicing of a single MAP-2 gene consisting of 20 exons. Studies are now being directed toward understanding the role of the multiple MAP-2 forms that contain novel exons in the nervous system. The expression, localization, and possible functions of the newly identified spliced forms are the focus of this review.

Original languageEnglish (US)
Pages (from-to)149-162
Number of pages14
JournalMolecular Neurobiology
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1998

Keywords

  • MAP-2
  • MAP-2 gene structure
  • MAP-2 transcripts
  • Microtubule-associated protein-2

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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